104425-36-7

Upstream product

• 26159-34-2 Naprelan 
• 15307-79-6 diclofenac sodium 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 15307-86-5 [2-(2,6-dichloroanilino)phenyl]acetic acid 

Downstream Products

• 216875-76-2 (S)-2-{2-[2-(2,6-Dichloro-phenylamino)-phenyl]-acetylamino}-4-methylsulfanyl-butyric acid ethyl ester 
• 216875-90-0 (2-{2-[2-(2,6-dichloro-phenylamino)-phenyl]-acetylamino}-acetylamino)-acetic acid methyl ester 
• 69630-31-5 acetylglycine 
• 192377-01-8 {2-[2-(2,6-Dichloro-phenylamino)-phenyl]-acetylamino}-acetic acid methyl ester 
• 683748-94-9 C₁₈H₂₀Cl₂N₂O₃ 

Relevant academic research and scientific papers

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis

We report the synthesis of a series of hybrid compounds incorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clinically used NSAIDs (indomethacin, sulindac, ketoprofen, ibuprofen, diclofenac, ketorolac, etc., cyclooxygenase inhibitors) as agents for the management of rheumatoid arthritis (RA). Most compounds were effective in inhibiting the RA overexpressed hCA IX and XII, with KI values in the low nanomolar-subnanomolar ranges. The antihyperalgesic activity of such compounds was assessed by means of the paw-pressure and incapacitance tests using an in vivo RA model. Among all tested compounds, the 7-coumarine hybrid with ibuprofen showed potent and persistent antihyperalgesic effect up to 60 min after administration.

Salt metathesis for developing injectable supramolecular metallohydrogelators as a multi-drug-self-delivery system

Salt metathesis has been exploited to generate a series of non-steroidal anti-inflammatory drug (NSAID) based Zn(ii) metallohydrogels displaying both anti-inflammatory and anti-bacterial properties. Relatively low cytotoxicity, rheoreversibility and injec

N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF

ABSTRACT Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux thr

Synthesis and comparative anti-phlogistic potency of new proteinogenic amino acid conjugates of 2-[2,6-dichlorophenyl-1-amino]phenyl acetic acid 'Diclofenac'

New proteinogenic amino acids conjugates of 2-[2,6-dichlorophenyl-1-amino]phenyl acetic acid 'Diclofenac', [I] were synthesized. Glycine methyl ester and L-methionine ethyl ester were coupled with [I] via the active ester method to give the corresponding 2-[2,6-dichlorophenyl-1-amino]benzyl carboxy N-amino acid ester of the type [IIa, b], respectively, which were hydrolyzed in alkaline medium to yield the free amino acids [IIIa, b]. Condensation of IIIa with glycine methyl ester using a modified classical carbodiimide (DCCI) method gave the corresponding 'Diclofenac' glycylglycine methyl ester [IVa]. Hydrolysis of compounds IVa gives the corresponding acid Va. Thionation of compounds IIb and IVa by reaction with Lewesson's Reagent (LR), afforded the corresponding thio-analogues (VIa and IVb). Interestingly, while retaining considerable comparative anti-phlogistic activity (anti-inflammatory and analgesic), the synthesized candidates proved to be practically nonulcerogenic in rats.