5-Bromo-4-chloro-2,6-dimethylpyrimidine

Base Information

• Chemical Name: 5-Bromo-4-chloro-2,6-dimethylpyrimidine
• CAS No.: 69696-35-1
• Molecular Formula: C6H6BrClN2
• Molecular Weight: 221.48200
• Hs Code.: 2933599090
• European Community (EC) Number: 841-662-8
• DSSTox Substance ID: DTXSID80500215
• Nikkaji Number: J240.033B
• Wikidata: Q82351640
• Mol file: 69696-35-1.mol

Synonyms:5-Bromo-4-chloro-2,6-dimethylpyrimidine;69696-35-1;SCHEMBL15055302;DTXSID80500215;BZQXOFCIHJDLCR-UHFFFAOYSA-N;MFCD13705450;AKOS015151317;SB60628;AS-63977;CS-0133913;EN300-107350;5-Bromo-4-chloro-2 pound not6-dimethylpyrimidine;A866780;A1-10919;Z1269230848

Chemical Property of 5-Bromo-4-chloro-2,6-dimethylpyrimidine

Chemical Property:

• Melting Point: 45 °C
• Boiling Point: 264.9±35.0 °C(Predicted)
• PKA: -0.23±0.39(Predicted)
• PSA: 25.78000
• Density: 1.621±0.06 g/cm3(Predicted)
• LogP: 2.50930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 219.94029
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-4-chloro-2,6-dimethylpyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC(=N1)C)Cl)Br

Technology Process of 5-Bromo-4-chloro-2,6-dimethylpyrimidine

There total 4 articles about 5-Bromo-4-chloro-2,6-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-bromo-2,6-dimethylpyrimidin-4-ol (858269-28-0) → 5-bromo-4-chloro-2,6-dimethylpyrimidine (69696-35-1)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 3h;

Reference yield:

4-hydroxy 2,6-dimethylpyrimidine (6622-92-0) → 5-bromo-4-chloro-2,6-dimethylpyrimidine (69696-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / 1,4-dioxane / 0.75 h / 20 °C

2: trichlorophosphate / 3 h / 110 °C

With bromine; trichlorophosphate; In 1,4-dioxane;

Reference yield:

5-bromo-2,6-dimethyl-3H-pyrimidin-4-one (858269-28-0) → 5-bromo-4-chloro-2,6-dimethylpyrimidine (69696-35-1)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

5-bromo-2,6-dimethyl-3H-pyrimidin-4-one

2,6-dimethyl-1H-pyrimidin-4-one

5-bromo-2,6-dimethylpyrimidin-4-ol

4-hydroxy 2,6-dimethylpyrimidine

Downstream raw materials:

3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate