3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Name:3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445787-42-7
Molecular Formula:C₂₆H₂₅N₅O₄
Molecular Weight:471.516
Hs Code.:

Synonyms:

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 9 articles about 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55076-32-9
methyl 3-hydroxy-5-nitrobenzoate

: 1445787-42-7
3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 120 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3.1: acetic acid / 1 h / 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.75 h / 110 °C / Microwave irradiation

4.2: 1 h / 110 °C / Microwave irradiation

5.1: potassium hydroxide / tetrahydrofuran; methanol / 4 h / 35 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; acetic acid; bis(pinacol)diborane; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 6622-92-0
4-hydroxy 2,6-dimethylpyrimidine

: 1445787-42-7
3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / 1,4-dioxane / 0.75 h / 20 °C

2.1: trichlorophosphate / 3 h / 110 °C

3.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C

3.2: 1.5 h / 90 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.75 h / 110 °C / Microwave irradiation

4.2: 1 h / 110 °C / Microwave irradiation

5.1: potassium hydroxide / tetrahydrofuran; methanol / 4 h / 35 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; potassium carbonate; toluene-4-sulfonic acid hydrazide; bis(pinacol)diborane; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform;

Reference yield:

: 858269-28-0
5-bromo-2,6-dimethylpyrimidin-4-ol

: 1445787-42-7
3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 3 h / 110 °C

2.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C

2.2: 1.5 h / 90 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.75 h / 110 °C / Microwave irradiation

3.2: 1 h / 110 °C / Microwave irradiation

4.1: potassium hydroxide / tetrahydrofuran; methanol / 4 h / 35 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; toluene-4-sulfonic acid hydrazide; bis(pinacol)diborane; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform;