1,2,3,4-tetrahydroquinoline-8-carbaldehyde

Base Information

• Chemical Name: 1,2,3,4-tetrahydroquinoline-8-carbaldehyde
• CAS No.: 69906-07-6
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol file: 69906-07-6.mol

Synonyms:1,2,3,4-Tetrahydro-quinoline-8-carbaldehyde;8-Formyl-1,2,3,4-tetrahydrochinolin;

Chemical Property of 1,2,3,4-tetrahydroquinoline-8-carbaldehyde

Chemical Property:

• PSA: 29.10000
• LogP: 1.99520

Purity/Quality:

99% ^*data from raw suppliers

1,2,3,4-tetrahydroquinoline-8-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-tetrahydroquinoline-8-carbaldehyde

There total 6 articles about 1,2,3,4-tetrahydroquinoline-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

8-formylquinoline (38707-70-9) → 1,2,3,4-tetrahydroquinoline-8-carbaldehyde (69906-07-6)

Guidance literature:

With ruthenium; hydrogen; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 80 ℃; for 36h; under 22502.3 Torr; chemoselective reaction; Autoclave;

DOI:10.1002/anie.201507945

Reference yield: 60.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + Cyclohexyl isocyanide (931-53-3) → 1,2,3,4-tetrahydroquinoline-8-carbaldehyde (69906-07-6)

Guidance literature:

1,2,3,4-tetrahydroisoquinoline; With boron trichloride; In 1,2-dichloro-ethane; for 2h; Inert atmosphere; Reflux;

Cyclohexyl isocyanide; With triethylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 1.5h;

With water;

DOI:10.1002/anie.202007799

Reference yield: 51.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + cyclohexane carbonitrile (766-05-2) → 1,2,3,4-tetrahydroquinoline-8-carbaldehyde (69906-07-6)

Guidance literature:

1,2,3,4-tetrahydroisoquinoline; With boron trichloride; In 1,2-dichloro-ethane; for 2h; Reflux;

cyclohexane carbonitrile; With triethylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 3h; Cooling;

DOI:10.1055/a-1559-2728

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

8-formylquinoline

Cyclohexyl isocyanide

cyclohexane carbonitrile

Downstream raw materials:

(E)-N-((1,2,3,4-tetrahydroquinolin-8-yl)methylene)-2-methylcyclohexan-1-amine

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