5-AMINO-2,4-DIHYDROXYBENZOIC ACID

Base Information

• Chemical Name: 5-AMINO-2,4-DIHYDROXYBENZOIC ACID
• CAS No.: 69938-56-3
• Molecular Formula: C7H7NO4
• Molecular Weight: 169.137
• Hs Code.: 2922509090
• Mol file: 69938-56-3.mol

Synonyms:Benzoic acid,5-amino-2,4-dihydroxy;5-amino-2,4-dihydroxy-benzoic acid;5-Amino-2,4-dihydroxy-benzoesaeure;

Chemical Property of 5-AMINO-2,4-DIHYDROXYBENZOIC ACID

Chemical Property:

• Boiling Point: 495.8±30.0 °C(Predicted)
• PKA: 2.13±0.10(Predicted)
• PSA: 103.78000
• Density: 1.672±0.06 g/cm3(Predicted)
• LogP: 0.95940
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-2,4-dihydroxybenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-AMINO-2,4-DIHYDROXYBENZOIC ACID

There total 2 articles about 5-AMINO-2,4-DIHYDROXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2,4-dihydroxy-5-nitrobenzoic acid (13722-96-8) → 5-amino-2,4-dihydroxybenzoic acid (69938-56-3)

Guidance literature:

2,4-dihydroxy-5-nitrobenzoic acid; With hydrazine hydrate; palladium on activated charcoal; In ethanol; for 4h; Reflux;

With hydrogenchloride; tin(ll) chloride; In ethanol; water; for 6h;

Reference yield:

recorcinol (108-46-3) → 5-amino-2,4-dihydroxybenzoic acid (69938-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sodium hydrogencarbonate / 3 h / 100 °C

2.1: nitric acid / acetonitrile / 3.5 h / 35 - 50 °C

3.1: hydrazine hydrate; palladium on activated charcoal / ethanol / 4 h / Reflux

3.2: 6 h

With hydrazine hydrate; palladium on activated charcoal; water; nitric acid; sodium hydrogencarbonate; In ethanol; acetonitrile; 1.1: |Kolbe-Schmidt Synthesis;

upstream raw materials:

2,4-dihydroxy-5-nitrobenzoic acid

recorcinol

Refernces

• 1、 -. "Preparation method for 5-amino-2,4-dihydroxybenzoic acid". Paragraph 0044; 0045; 0046; 0047; 0048; 0049; 0050-0054. . Retrieved 2019/04/26.