Technology Process of 5-bromo-3-phenyl-1H-indole-2-carbohydrazide
There total 5 articles about 5-bromo-3-phenyl-1H-indole-2-carbohydrazide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
for 5h;
Heating;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 5 °C / Inert atmosphere
1.2: 72 °C / Inert atmosphere
2.1: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C
2.2: 17 h / 0 - 4 °C
3.1: hydrogenchloride / water / 4 h / 80 °C
4.1: hydrazine / ethanol; water / 80 °C
With
hydrogenchloride; sodium hydride; hydrazine; sodium nitrite;
In
tetrahydrofuran; ethanol; water; mineral oil;
2.2: |Japp-Klingemann Hydrazone Synthesis / 3.1: |Fischer Indole Synthesis;
DOI:10.1016/j.bioorg.2021.104795
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C
1.2: 17 h / 0 - 4 °C
2.1: hydrogenchloride / water / 4 h / 80 °C
3.1: hydrazine / ethanol; water / 80 °C
With
hydrogenchloride; hydrazine; sodium nitrite;
In
ethanol; water;
1.2: |Japp-Klingemann Hydrazone Synthesis / 2.1: |Fischer Indole Synthesis;
DOI:10.1016/j.bioorg.2021.104795