5-bromo-3-phenyl-1H-indole-2-carbohydrazide

Base Information

Chemical Name:5-bromo-3-phenyl-1H-indole-2-carbohydrazide
CAS No.:70070-24-5
Molecular Formula:C15H12BrN3O
Molecular Weight:330.184
Hs Code.:
DSSTox Substance ID:DTXSID20359183
Wikidata:Q82140257
ChEMBL ID:CHEMBL1325942

Synonyms:5-bromo-3-phenyl-1H-indole-2-carbohydrazide;70070-24-5;MLS000769266;SCHEMBL7560999;CHEMBL1325942;DTXSID20359183;HMS2797F14;STL336856;AKOS022133398;SMR000434000;5-Bromo-3-phenyl-1H-indole-2-carboxylic acid hydrazide

Suppliers and Price of 5-bromo-3-phenyl-1H-indole-2-carbohydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-bromo-3-phenyl-1H-indole-2-carbohydrazide

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:329.01637
Heavy Atom Count:20
Complexity:359

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(NC3=C2C=C(C=C3)Br)C(=O)NN

Technology Process of 5-bromo-3-phenyl-1H-indole-2-carbohydrazide

There total 5 articles about 5-bromo-3-phenyl-1H-indole-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59394-42-2
ethyl 5-bromo-3-phenyl-1H-indole-2-carboxylate

: 70070-24-5
5-bromo-3-phenylindole-2-carboxyhydrazide

Guidance literature:: With hydrazine hydrate; for 5h; Heating;

Reference yield:

: 100-39-0
benzyl bromide

: 70070-24-5
5-bromo-3-phenylindole-2-carboxyhydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 5 °C / Inert atmosphere

1.2: 72 °C / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C

2.2: 17 h / 0 - 4 °C

3.1: hydrogenchloride / water / 4 h / 80 °C

4.1: hydrazine / ethanol; water / 80 °C

With hydrogenchloride; sodium hydride; hydrazine; sodium nitrite; In tetrahydrofuran; ethanol; water; mineral oil; 2.2: |Japp-Klingemann Hydrazone Synthesis / 3.1: |Fischer Indole Synthesis;
DOI:10.1016/j.bioorg.2021.104795

Reference yield:

: 620-79-1
Ethyl 2-benzylacetoacetate

: 70070-24-5
5-bromo-3-phenylindole-2-carboxyhydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C

1.2: 17 h / 0 - 4 °C

2.1: hydrogenchloride / water / 4 h / 80 °C

3.1: hydrazine / ethanol; water / 80 °C

With hydrogenchloride; hydrazine; sodium nitrite; In ethanol; water; 1.2: |Japp-Klingemann Hydrazone Synthesis / 2.1: |Fischer Indole Synthesis;
DOI:10.1016/j.bioorg.2021.104795