Benzene, 1-fluoro-4-(2-methyl-1-propenyl)-

Base Information

• Chemical Name: Benzene, 1-fluoro-4-(2-methyl-1-propenyl)-
• CAS No.: 702-09-0
• Molecular Formula: C10H11F
• Molecular Weight: 150.196
• Mol file: 702-09-0.mol

Synonyms:

Chemical Property of Benzene, 1-fluoro-4-(2-methyl-1-propenyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-fluoro-4-(2-methyl-1-propenyl)-

There total 10 articles about Benzene, 1-fluoro-4-(2-methyl-1-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(4-fluoro-phenyl)-2-methyl-propan-1-ol (1766-28-5) → 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene (702-09-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 0.666667h; Heating;

DOI:10.1021/jo00115a016

Reference yield: 75.0%

2-phenyl-indole (948-65-2) + C11H12FN (1397290-31-1) → 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene (702-09-0) + 3-(4-fluorophenyl)-2-methyl-propene (702-08-9) + 2-phenyl-1H-indole-3-carbonitrile (51072-85-6)

Guidance literature:

With palladium diacetate; copper(II) trifluoroacetate; In 1,2-dichloro-ethane; at 70 ℃; for 1h;

DOI:10.1021/ol302372p

Reference yield: 67.0%

isopropyltriphenylphosphonium iodide (24470-78-8) + 4-fluorobenzaldehyde (459-57-4) → 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene (702-09-0)

Guidance literature:

isopropyltriphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Inert atmosphere;

4-fluorobenzaldehyde; In tetrahydrofuran; hexane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.1c12043

upstream raw materials:

1-(4-fluorophenyl)-2-methylpropan-2-ol

isobutyraldehyde

1-Bromo-4-fluorobenzene

1-(4-fluoro-phenyl)-2-methyl-propan-1-ol

Downstream raw materials:

1-(4-fluorophenyl)-2-methylpropan-2-amine

Refernces

• 1、 Occhialini, Gino,Palani, Vignesh,Wendlandt, Alison E.. "Catalytic, contra-Thermodynamic Positional Alkene Isomerization". supporting information. p. 145 - 152. Retrieved 2022/01/19.
• 2、 Doobary, Sayad,Sedikides, Alexi T.,Caldora, Henry P.,Poole, Darren L.,Lennox, Alastair J. J.. "Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates". supporting information. p. 1155 - 1160. Retrieved 2019/12/11.