1-[(4-Methoxyphenyl)-methyl]-azetidin-2-one

Base Information

• Chemical Name: 1-[(4-Methoxyphenyl)-methyl]-azetidin-2-one
• CAS No.: 70875-47-7
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• DSSTox Substance ID: DTXSID001271181
• Mol file: 70875-47-7.mol

Synonyms:1-p-anisylazetidin-2-one;70875-47-7;SCHEMBL11432095;DTXSID001271181;AKOS015907509;1-[(4-Methoxyphenyl)methyl]-2-azetidinone;1-[(4-methoxyphenyl)-methyl]-azetidin-2-one

Chemical Property of 1-[(4-Methoxyphenyl)-methyl]-azetidin-2-one

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 191.094628657
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CN2CCC2=O

Technology Process of 1-[(4-Methoxyphenyl)-methyl]-azetidin-2-one

There total 4 articles about 1-[(4-Methoxyphenyl)-methyl]-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-bromo-N-(4-methoxy-benzyl)-propionamide (70875-41-1) → 1-(4'-methoxyphenylmethyl)azetidin-2-one (70875-47-7)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane; acetonitrile; for 6.5h; Ambient temperature;

Reference yield: 35.0%

[(1-Ethoxycyclopropyl)oxy]trimethylsilane (27374-25-0) + 1-(azidomethyl)-4-methoxybenzene (70978-37-9) → N-(4-methoxyphenylmethyl)carbamic acid ethyl ester (35573-36-5) + 1-(4'-methoxyphenylmethyl)azetidin-2-one (70875-47-7)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo0711034

Reference yield:

4-methoxy-benzylamine (2393-23-9) → 1-(4'-methoxyphenylmethyl)azetidin-2-one (70875-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / N,N-dimethylaniline / CH₂Cl₂ / 2 h / Ambient temperature

2: 85 percent / pulv. KOH / tetra-n-butylammonium bromide / CH₂Cl₂; acetonitrile / 6.5 h / Ambient temperature

With potassium hydroxide; N,N-dimethyl-aniline; tetrabutylammomium bromide; In dichloromethane; acetonitrile;

upstream raw materials:

3-bromo-N-(4-methoxy-benzyl)-propionamide

N-(p-Methoxybenzyl)-2-(carbo-tert-butoxy)azetidine

[(1-Ethoxycyclopropyl)oxy]trimethylsilane

1-(azidomethyl)-4-methoxybenzene