N,N-Dimethyl-2-(phenylsulfanyl)propanamide

Base Information

• Chemical Name: N,N-Dimethyl-2-(phenylsulfanyl)propanamide
• CAS No.: 71364-46-0
• Molecular Formula: C11H15NOS
• Molecular Weight: 209.312
• DSSTox Substance ID: DTXSID60501104
• Mol file: 71364-46-0.mol

Synonyms:71364-46-0;N,N-Dimethyl-2-(phenylsulfanyl)propanamide;N,N-dimethyl-2-phenylsulfanylpropanamide;DTXSID60501104;AKOS016453234;Z32013723

Chemical Property of N,N-Dimethyl-2-(phenylsulfanyl)propanamide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 209.08743528
• Heavy Atom Count: 14
• Complexity: 188

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)N(C)C)SC1=CC=CC=C1

Technology Process of N,N-Dimethyl-2-(phenylsulfanyl)propanamide

There total 5 articles about N,N-Dimethyl-2-(phenylsulfanyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophenol (108-98-5) + 2-chloro-N,N-dimethyl-propionamide (10397-68-9,152786-29-3) → α-phenylthio-N,N-dimethylpropionamide (71364-46-0)

Guidance literature:

With sodium; In ethanol; at 20 ℃; for 16h;

DOI:10.1039/b618540a

Reference yield:

2-bromo-N,N-dimethylpropanamide (54537-47-2) + thiophenol (108-98-5) → α-phenylthio-N,N-dimethylpropionamide (71364-46-0)

Guidance literature:

With sodium ethanolate; In ethanol; for 12h; Ambient temperature;

Reference yield:

(R)-α-(phenylthio)propanoic acid (146300-52-9) → (R)-2-phenylsulfanyl-propionic acid dimethylamide (71364-46-0)

Guidance literature:

With thionyl chloride; Eintragen des gebildeten Saeurechlorids in eine Loesung von Dimethylamin in Chloroform;

upstream raw materials:

2-bromo-N,N-dimethylpropanamide

thiophenol

2-chloro-N,N-dimethyl-propionamide

(R)-α-(phenylthio)propanoic acid

Downstream raw materials:

N,N-dimethyl-E-3-chloro-2-(phenylthio)propenamide

N,N-dimethyl-3-oxo-2-(phenylsulfanyl)propanamide

(2S,5R)-6-(2-Benzenesulfinyl-2-dimethylcarbamoyl-ethyl)-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

(2S,5R)-6-Bromo-6-((E)-2-dimethylcarbamoyl-vinyl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester