Technology Process of (2S,5R)-6-(2-Benzenesulfinyl-2-dimethylcarbamoyl-ethyl)-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester
There total 9 articles about (2S,5R)-6-(2-Benzenesulfinyl-2-dimethylcarbamoyl-ethyl)-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 3.6 g / sodium ethoxide / ethanol / 12 h / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2 / 1 h / -78 °C
3: 1.) potassium hydride / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C
4: 1.) m-chloroperbenzoic acid / 1.) dichloromethane, -78 deg C, 15 min, 2.) -78 deg C -> room temperature
5: 1.) methylmagnesium bromide / 1.) THF, ether, -78 deg C, 20 min, 2.) -70 deg C, 0.5 h, -60 deg C, 1 h
With
methylmagnesium bromide; sodium ethanolate; potassium hydride; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) sodium amide / 1.) liquid ammonia, THF, -20 deg C, 0.5 h, 2.) reflux, 15 min
2: m-chloroperbenzoic acid / CHCl3 / 0 °C
3: CHCl3 / 3 h / Heating
4: 1.) methylmagnesium bromide / 1.) THF, ether, -78 deg C, 20 min, 2.) -70 deg C, 0.5 h, -60 deg C, 1 h
With
methylmagnesium bromide; sodium amide; 3-chloro-benzenecarboperoxoic acid;
In
chloroform;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: m-chloroperbenzoic acid / CH2Cl2 / 1 h / -78 °C
2: 1.) potassium hydride / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C
3: 1.) m-chloroperbenzoic acid / 1.) dichloromethane, -78 deg C, 15 min, 2.) -78 deg C -> room temperature
4: 1.) methylmagnesium bromide / 1.) THF, ether, -78 deg C, 20 min, 2.) -70 deg C, 0.5 h, -60 deg C, 1 h
With
methylmagnesium bromide; potassium hydride; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
