2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine

Base Information

Chemical Name:2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine
CAS No.:75306-60-4
Molecular Formula:C23H32 Cl N O4
Molecular Weight:421.964
Hs Code.:
European Community (EC) Number:278-184-9
DSSTox Substance ID:DTXSID60996758
Nikkaji Number:J307.556G
Mol file:75306-60-4.mol

Synonyms:75306-60-4;EINECS 278-184-9;2-CHLORO-N-[2-(1,1-DIMETHYLETHOXY)-2-(4-METHOXYPHENYL)ETHYL]-3,4-DIMETHOXYPHENETHYLAMINE;2-Chloro-N-(2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl)-3,4-dimethoxyphenethylamine;C23H32ClNO4;SCHEMBL11262922;C23-H32-Cl-N-O4;DTXSID60996758;2-tert-Butoxy-N-[2-(2-chloro-3,4-dimethoxyphenyl)ethyl]-2-(4-methoxyphenyl)ethan-1-amine;2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxybenzeneethanamine

Suppliers and Price of 2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine

Chemical Property:

Vapor Pressure:1.11E-10mmHg at 25°C
Boiling Point:514.1°C at 760 mmHg
Flash Point:264.7°C
PSA：48.95000
Density:1.104g/cm³
LogP:5.44520
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:421.2019862
Heavy Atom Count:29
Complexity:451

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(CNCCC1=C(C(=C(C=C1)OC)OC)Cl)C2=CC=C(C=C2)OC

Technology Process of 2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine

There total 10 articles about 2-Chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67287-36-9
2-(2-chloro-3,4-dimethoxyphenyl)ethylamine

: 72912-33-5
2-bromo-1-(tert-butoxy)-1-(4-methoxyphenyl)ethane

: 75306-60-4
[2-tert-Butoxy-2-(4-methoxy-phenyl)-ethyl]-[2-(2-chloro-3,4-dimethoxy-phenyl)-ethyl]-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 2h;
DOI:10.1021/jm00161a029

Reference yield:

: 621-59-0
isovanillin

: 75306-60-4
[2-tert-Butoxy-2-(4-methoxy-phenyl)-ethyl]-[2-(2-chloro-3,4-dimethoxy-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Cl₂

2: 66 percent / K₂CO₃ / dimethylformamide / 0.08 h / Heating

3: 100 percent / NaBH₄ / aq. ethanol / 1 h / 25 °C

4: 97 percent / 12N aq. HCl

5: 96 percent / dimethylsulfoxide / 1.25 h

6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating

7: K₂CO₃ / dimethylformamide / 2 h / 110 °C

With hydrogenchloride; sodium tetrahydroborate; borane; chlorine; potassium carbonate; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 75306-60-4
[2-tert-Butoxy-2-(4-methoxy-phenyl)-ethyl]-[2-(2-chloro-3,4-dimethoxy-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 86.4 percent / Br₂ / CH₂Cl₂ / -5 - 0 °C

2: 95 percent / MgSO₄, MgO / 1.25 h / Heating

3: K₂CO₃ / dimethylformamide / 2 h / 110 °C

With bromine; magnesium oxide; magnesium sulfate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029