Fenoldopam Hydrobromide

Base Information

• Chemical Name: Fenoldopam Hydrobromide
• CAS No.: 67287-54-1
• Molecular Formula: C16H15BrClNO3
• Molecular Weight: 386.673
• European Community (EC) Number: 266-634-7
• UNII: 2BQI8R8GEM
• DSSTox Substance ID: DTXSID501017273
• Wikidata: Q27254530
• ChEMBL ID: CHEMBL1256646
• Mol file: 67287-54-1.mol

Synonyms:Corlopam;Fenoldopam;Fenoldopam Hydrobromide;Fenoldopam Mesylate;Hydrobromide, Fenoldopam;SK and F 82526;SK and F 82526J;SK and F-82526;SK and F-82526J;SK and F82526;SK and F82526J;SKF 82526;SKF 82526J;SKF-82526;SKF-82526J;SKF82526;SKF82526J

Chemical Property of Fenoldopam Hydrobromide

Chemical Property:

• Vapor Pressure: 1.53E-11mmHg at 25°C
• Melting Point: >233°C (dec.)
• Boiling Point: 522.6°Cat760mmHg
• Flash Point: 269.9°C
• PSA: 72.72000
• Density: 1.38g/cm³
• LogP: 4.02130
• Storage Temp.: 2-8°C
• Solubility.: DMSO: >12mg/mL
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 385.00803
• Heavy Atom Count: 22
• Complexity: 348

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fenoldopam Hydrobromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36-42/43
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O.Br
• Uses: Fenoldopam Monohydrobromide is a potent D-1 dopamine agonists.

Technology Process of Fenoldopam Hydrobromide

There total 16 articles about Fenoldopam Hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (67287-53-0) → Fenoldopam hydrobromide (67287-54-1)

Guidance literature:

With boron tribromide; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1021/jm00161a029

Reference yield: 88.6%

→ Fenoldopam hydrobromide (67287-54-1)

Guidance literature:

Reference yield: 73.5%

N-[2-hydroxy-2-(4'-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine (71636-38-9) → Fenoldopam hydrobromide (67287-54-1)

Guidance literature:

N-[2-hydroxy-2-(4'-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine; With sulfuric acid; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

With ammonia; water; In dichloromethane; at 20 ℃;

With hydrogen bromide; In water; at 107 ℃; for 16h;

upstream raw materials:

6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

isovanillin

4-Methoxystyrene

2-chloro-3,4-dimethoxybenzyl chloride

Downstream raw materials:

fenoldopam