(4-METHOXYPHENYL)(2-NITROPHENYL)METHANONE

Base Information

• Chemical Name: (4-METHOXYPHENYL)(2-NITROPHENYL)METHANONE
• CAS No.: 73376-03-1
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.24100
• Mol file: 73376-03-1.mol

Synonyms:4-methoxy-2'-nitrobenzophenone;4'-Methoxy-2-nitro-benzophenon;2-Nitro-4'-methoxybenzophenone;4'-methoxy-2-nitro-benzophenone;

Chemical Property of (4-METHOXYPHENYL)(2-NITROPHENYL)METHANONE

Chemical Property:

• PSA: 72.12000
• LogP: 3.35760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-METHOXYPHENYL)(2-NITROPHENYL)METHANONE

There total 7 articles about (4-METHOXYPHENYL)(2-NITROPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-methoxy-phenyl)-(2-nitro-phenyl)-methanol (100476-07-1) → (4-methoxyphenyl)(2-nitrophenyl)methanone (73376-03-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 47h; Heating;

DOI:10.3987/com-03-9926

Reference yield: 33.0%

methoxybenzene (100-66-3) + 2-nitrobenzyl chloride (610-14-0) → (4-methoxyphenyl)(2-nitrophenyl)methanone (73376-03-1)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; toluene; at 20 - 40 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3ra46392c

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) + methoxybenzene (100-66-3) + trifluoroacetic anhydride (407-25-0) → (4-methoxyphenyl)(2-nitrophenyl)methanone (73376-03-1)

Guidance literature:

With boron trifluoride;

DOI:10.1021/ja01513a051

upstream raw materials:

ortho-nitrobenzoic acid

methoxybenzene

trifluoroacetic anhydride

2-nitrobenzyl chloride

Downstream raw materials:

2-amino-4'-methoxybenzophenone

3-(4-methoxyphenyl)benzo[c]isoxazole

(4-methoxy-phenyl)-(2-nitro-phenyl)-methanol

(4-hydroxyphenyl)(2-nitrophenyl)methanone