N-(2,6-Dioxo-3-piperidyl)phthalamic acid

Base Information

Chemical Name:N-(2,6-Dioxo-3-piperidyl)phthalamic acid
CAS No.:6139-18-0
Molecular Formula:C13H12 N2 O5
Molecular Weight:276.249
Hs Code.:2924299090
DSSTox Substance ID:DTXSID90927030
Nikkaji Number:J2.440.237A
ChEMBL ID:CHEMBL4578369
Mol file:6139-18-0.mol

Synonyms:o-Cgai;6139-18-0;N-(2,6-Dioxo-3-piperidyl)phthalamic acid;BRN 0492204;N-(o-Carboxybenzoyl)-D,L-glutamic acid imide;N-(o-Carboxybenzoyl)-DL-glutaminsaureimid [German];Phthalamic acid, N-(2,6-dioxo-3-piperidyl)-, DL-;alpha-(o-Carboxybenzamido) glutarimide;N-(o-Carboxybenzoyl)-DL-glutaminsaureimid;131-68-0;Benzoic acid,2-(((2,6-dioxo-3-piperidinyl)amino)carbonyl)-;C13H12N2O5;2-((2,6-dioxopiperidin-3-yl)carbamoyl)benzoic acid;SCHEMBL4778728;CHEMBL4578369;DTXSID90927030;a-(o-carboxybenzamido) glutarimide;Benzoic acid, 2-[[(2,6-dioxo-3-piperidinyl)amino]carbonyl]-;AKOS015298178;LS-109083;2-(2,6-Dioxo-3-piperidinylcarbamoyl)benzoic acid;2-{Hydroxy[(6-hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)imino]methyl}benzoic acid

Suppliers and Price of N-(2,6-Dioxo-3-piperidyl)phthalamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-(2,6-Dioxo-3-piperidyl)phthalamic acid

Chemical Property:

Vapor Pressure:3.73E-17mmHg at 25°C
Boiling Point:638.1°C at 760 mmHg
Flash Point:339.7°C
PSA：119.55000
Density:1.47g/cm³
LogP:0.77050
XLogP3:0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:276.07462149
Heavy Atom Count:20
Complexity:448

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC(=O)C1NC(=O)C2=CC=CC=C2C(=O)O

Technology Process of N-(2,6-Dioxo-3-piperidyl)phthalamic acid

There total 5 articles about N-(2,6-Dioxo-3-piperidyl)phthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: α-(2-(benzyloxycarbonyl)benzamido)glutarimide

: 6139-18-0,131-68-0,29883-18-9
N-(o-Carboxybenzoyl)-D,L-glutamic acid imide

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1248/cpb.55.651

Reference yield:

: 85535-45-1
5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid

: 6139-18-0,131-68-0,29883-18-9
N-(o-Carboxybenzoyl)-D,L-glutamic acid imide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / 1,1'-carbonyldiimidazole; 4-dimethylaminopyridine; triethylamine / tetrahydrofuran / 72 h / 20 °C

2.1: 98 percent / HBr; aq. AcOH / 0.5 h / 20 °C

3.1: methyl chloroformate; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

3.2: 37 percent / tetrahydrofuran / 4.75 h / 0 - 20 °C

4.1: 80 percent / H₂ / Pd/C / dioxane / 2 h / 20 °C

With dmap; hydrogen bromide; hydrogen; acetic acid; triethylamine; methyl chloroformate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1248/cpb.55.651

Reference yield:

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

: 6139-18-0,131-68-0,29883-18-9
N-(o-Carboxybenzoyl)-D,L-glutamic acid imide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / HBr; aq. AcOH / 0.5 h / 20 °C

2.1: methyl chloroformate; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

2.2: 37 percent / tetrahydrofuran / 4.75 h / 0 - 20 °C

3.1: 80 percent / H₂ / Pd/C / dioxane / 2 h / 20 °C

With hydrogen bromide; hydrogen; acetic acid; triethylamine; methyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1248/cpb.55.651