Glutamine,N2-[(1,1-dimethylethoxy)carbonyl]-

Base Information

• Chemical Name: Glutamine,N2-[(1,1-dimethylethoxy)carbonyl]-
• CAS No.: 85535-45-1
• Molecular Formula: C10H18N2O5
• Molecular Weight: 246.263

Synonyms:DL-Glutamine,N2-[(1,1-dimethylethoxy)carbonyl]-;(S)-5-Amino-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid;2-Boc-amino-4-carbamoylbutanoic acid;

Chemical Property of Glutamine,N2-[(1,1-dimethylethoxy)carbonyl]-

Chemical Property:

• Boiling Point: 509.1 °C at 760 mmHg
• Flash Point: 261.7 °C
• Density: 1.22 g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glutamine,N2-[(1,1-dimethylethoxy)carbonyl]-

There total 1 articles about Glutamine,N2-[(1,1-dimethylethoxy)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

tert-butyl 4,6-dimethoxy-1,3,5-triazinyl carbonate (909114-65-4) + GLUTAMINE (56-85-9,585-21-7,5959-95-5,6899-04-3,26700-71-0) → 5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid (85535-45-1)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 1h;

DOI:10.1055/s-2006-942389

Reference yield: 99.0%

5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid (85535-45-1) → (RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester (31140-42-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.3390/molecules26092525

Reference yield: 98.0%

O-benzyl-N-cyclohexyl-N-methylpolystyrene isourea + 5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid (85535-45-1) → N-tert-butoxycarbonylglutamine benzyl ester

Guidance literature:

In tetrahydrofuran; at 60 ℃; for 16h;

DOI:10.1021/jo049239e

upstream raw materials:

tert-butyl 4,6-dimethoxy-1,3,5-triazinyl carbonate

GLUTAMINE

Downstream raw materials:

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

N-(o-Carboxybenzoyl)-D,L-glutamic acid imide

DL-3-amino-2,6-piperidinone hydrobromide

2-(2,6-dioxo-3-piperidinyl)-5-benzyloxy-1H-isoindole-1,3(2H)-dione

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