Methyl 1-methyl-2-naphthoate

Base Information

• Chemical Name: Methyl 1-methyl-2-naphthoate
• CAS No.: 73721-17-2
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• European Community (EC) Number: 828-960-3
• Nikkaji Number: J3.185.870D
• Mol file: 73721-17-2.mol

Synonyms:Methyl 1-methyl-2-naphthoate;73721-17-2;methyl 1-methylnaphthalene-2-carboxylate;1-Methyl-naphthalene-2-carboxylic acid methyl ester;2-Naphthalenecarboxylic acid, 1-methyl-, methyl ester;Methyl1-methyl-2-naphthoate;SCHEMBL246068;AKOS027323075;SB38509;AS-43054;CS-0455390;EN300-304678;Z1509556875

Chemical Property of Methyl 1-methyl-2-naphthoate

Chemical Property:

• PSA: 26.30000
• LogP: 2.93480
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 237

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-Methyl-2-naphthoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC2=CC=CC=C12)C(=O)OC

Technology Process of Methyl 1-methyl-2-naphthoate

There total 7 articles about Methyl 1-methyl-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-methyl-5-phenyl-4,5-dihydrofuran-3-carboxylate (134391-10-9) → methyl 1-methyl-2-naphthoate (73721-17-2)

Guidance literature:

With 3,4,5-trimethylphenol; scandium tris(trifluoromethanesulfonate); at 0 - 20 ℃; for 6h;

DOI:10.1021/acs.orglett.7b03392

Reference yield: 98.0%

methyl 1-acetyl-2-phenylcyclopropanecarboxylate (144465-33-8) → methyl 1-methyl-2-naphthoate (73721-17-2)

Guidance literature:

With hafnium(IV) trifluoromethanesulfonate; 3,4,5-trimethylphenol; at 0 - 20 ℃; for 15h; Reagent/catalyst; Catalytic behavior; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03392

Reference yield: 86.0%

methyl 2-acetyl-4-(6-hydroxy-2,3,4-trimethylphenyl)-4-phenylbutanoate → methyl 1-methyl-2-naphthoate (73721-17-2)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); at 0 - 20 ℃; for 3h;

DOI:10.1021/acs.orglett.7b03392

upstream raw materials:

tetramethylstannane

1-hydroxy-naphthalene-2-carboxylic acid methyl ester

methyl magnesium iodide

methyl 1-methoxy-2-naphthoate

Downstream raw materials:

5-bromo-2-[(1S, 2S)-2-hydroxycyclohexyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one

5-ethenyl-2-[(1S,2S)-2-hydroxycyclohexyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one

2-[(1S,2S)-2-hydroxycyclohexyl]-3-oxo-2,3-dihydro-1H-benzo[e]isoindole-5-carbaldehyde

1-({2-[(1S,2S)-2-hydroxycyclohexyl]-3-oxo-2,3-dihydro-1H-benzo[e]isoindol-5-yl}methyl)-4-(pyridine-2-yl)piperidine-4-carbonitrile