Methyl 1-methoxy-2-naphthoate

Base Information

• Chemical Name: Methyl 1-methoxy-2-naphthoate
• CAS No.: 6039-59-4
• Molecular Formula: C13H12O3
• Molecular Weight: 216.236
• DSSTox Substance ID: DTXSID30405100
• Nikkaji Number: J47.501G
• Wikidata: Q63408873
• Mol file: 6039-59-4.mol

Synonyms:Methyl 1-methoxy-2-naphthoate;6039-59-4;Methyl 1-methoxynaphthalene-2-carboxylate;1-Methoxy-2-naphthoic acid methyl ester;SCHEMBL5963449;2-Naphthalenecarboxylic acid, 1-methoxy-, methyl ester;DTXSID30405100;IKYRLYKWULPUNA-UHFFFAOYSA-N;METHYL1-METHOXY-2-NAPHTHOATE;AKOS024319445;Methyl 1-methoxy-2-naphthoate, 98%;Methyl 1-methoxy-naphthalene-2-carboxylate;FT-0747869;Q63408873

Chemical Property of Methyl 1-methoxy-2-naphthoate

Chemical Property:

• Vapor Pressure: 4.69E-05mmHg at 25°C
• Melting Point: 127-128 °C
• Refractive Index: n20/D 1.603(lit.)
• Boiling Point: 320 °C(lit.)
• Flash Point: >230 °F
• PSA: 35.53000
• Density: 1.17 g/mL at 25 °C(lit.)
• LogP: 2.63500
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.078644241
• Heavy Atom Count: 16
• Complexity: 252

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl 1-methoxy-2-naphthoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C=CC2=CC=CC=C21)C(=O)OC
• Uses: Methyl 1-methoxy-2-naphthoate may be used to synthesize a precursor, required for the preparation of a naphthopyran derivative and (3,4-dihydro-3,3-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione).

Technology Process of Methyl 1-methoxy-2-naphthoate

There total 9 articles about Methyl 1-methoxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl iodide (74-88-4) + 1-hydroxy-2-naphthoic acid (86-48-6) → methyl 1-methoxy-2-naphthoate (6039-59-4)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

Reference yield: 96.0%

dimethyl sulfate (77-78-1) + 1-hydroxy-2-naphthoic acid (86-48-6) → methyl 1-methoxy-2-naphthoate (6039-59-4)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃; Temperature;

DOI:10.1002/ejoc.201901895

Reference yield: 93.0%

1-hydroxy-naphthalene-2-carboxylic acid methyl ester (948-03-8) + methyl iodide (74-88-4) → methyl 1-methoxy-2-naphthoate (6039-59-4)

Guidance literature:

1-hydroxy-naphthalene-2-carboxylic acid methyl ester; With potassium carbonate; In N,N-dimethyl-formamide; for 0.75h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.09.010

upstream raw materials:

1-hydroxy-naphthalene-2-carboxylic acid methyl ester

dimethyl sulfate

methyl iodide

diazomethane

Downstream raw materials:

(-)-menthyl 1-(-)-menthyloxy-2-naphthoate

2-(Hydroxymethyl)-1-methoxynaphthalene

(S)-1-phenylethyl 1-methoxy-2-naphthoate

l-p-menth-3-yl 1-methoxy-2-naphthoate