RU 18760

Base Information

• Chemical Name: RU 18760
• CAS No.: 64313-94-6
• Molecular Formula: C23H34 O6
• Molecular Weight: 406.519
• Mol file: 64313-94-6.mol

Synonyms:5b-Pregnane-3,20-dione, 11b,17,21-trihydroxy-, 21-acetate(6CI,7CI); 5b-Dihydrocortisol21-acetate; RU 18760

Chemical Property of RU 18760

Chemical Property:

• Melting Point: 208-213°C
• PSA: 100.90000
• LogP: 2.43230
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

5β-Dihydrocortisol21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cortisol derivatiove. Shows binding affinities for the cytosol glucocorticoid receptor.

Technology Process of RU 18760

There total 14 articles about RU 18760 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

5β-pregnane-11β,17α,21-triol-3,20-dione (1482-50-4,71973-95-0) + acetic anhydride (108-24-7) → RU 18760 (64313-94-6)

Guidance literature:

With pyridine; at 20 ℃;

Reference yield: 44.0%

hydrocortisone acetate (50-03-3) → RU 18760 (64313-94-6)

Guidance literature:

With pyridine; 10% Pd(OH)2 on carbon; hydrogen; at 20 ℃;

DOI:10.1248/cpb.58.344

Reference yield:

hydrocortisone acetate (50-03-3) → RU 18748 (4004-68-6) + RU 18760 (64313-94-6)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 5%-palladium/activated carbon; In ethanol; for 5h; Reagent/catalyst; Overall yield = 80 %; stereoselective reaction; Reflux;

DOI:10.1039/c3ra41519h

upstream raw materials:

11β,17-dihydroxy-3,3-dimethoxy-5β-pregnan-20-one

22-acetoxy-11β-hydroxy-3-oxo-23,24-dinor-5β-chol-17(20)ξ-ene-21-nitrile

21-acetoxy-3α,11β,17α-trihydroxy-5β-pregnan-20-one

aluminium(III) phenoxide

Downstream raw materials:

11β-hydroxyetiocholanolone

HYDROCORTISONE

17,21-dihydroxy-11,20-dioxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid

tetrahydrocortisol 21-glucuronide