50-03-3 Usage
Uses
1. Used in Pharmaceutical Industry:
Hydrocortisone acetate is used as an anti-inflammatory agent for reducing inflammation and alleviating pain in various conditions.
2. Used in Allergy Treatment:
Hydrocortisone acetate is used as an anti-allergic agent for treating allergic reactions and symptoms.
3. Used in Intestinal Treatment:
Hydrocortisone acetate is used as a treatment for certain intestinal problems, such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions, for reducing inflammation and promoting healing.
4. Used in Hemorrhoid Treatment:
Hydrocortisone acetate is used as a treatment for hemorrhoids and itching/swelling in the rectum and anus, providing relief from discomfort and promoting healing.
Adrenocorticotropic hormone drugs
Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216~222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α-hydroxy progesterone.
Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.
Indications
For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis.
Figure 1 the chemical structure formula of tetra-fluoroethane.
Contraindications
1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited.
2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited.
The above information is edited by the lookchem of KuiMing.
Adverse Reactions
Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection.
Precautions
1. Not long-term, large-scale use.
2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication.
Chemical Property
White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether.
Production methods
Hydrocortisone and acetic anhydride in pyridine esterification.
Clinical Use
Corticosteroid:
Local inflammation of joints and soft tissue
Drug interactions
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, phenobarbital, fosphenytoin,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by
ritonavir.
Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration of hydrocortisone possibly
increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines.
Purification Methods
The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]
Check Digit Verification of cas no
The CAS Registry Mumber 50-03-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 50-03:
(4*5)+(3*0)+(2*0)+(1*3)=23
23 % 10 = 3
So 50-03-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16?,17?,18-,20?,21-,22-,23-/m0/s1
50-03-3Relevant articles and documents
Dehalogenation methodof 9-halogenated steroid compound and application
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Paragraph 0164-0166, (2021/01/11)
The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.
Preparation process of hydrocortisone acetate
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Paragraph 0015, (2017/07/06)
The invention relates to a preparation process of hydrocortisone acetate. The preparation process comprises the following steps: under the action of 4-dimethylamiopryidine, enabling hydrocortisone and acetic anhydride to directly react, without the need of additionally utilizing a solvent; washing into water and separating out materials; filtering and drying to prepare the hydrocortisone acetate. The technical problem in the prior art that a reaction process commonly needs pyridine or a pyridine substitute solvent is overcome; the large-batch production capability of a reaction kettle is greatly improved and a condition that a lot of industrial wastewater difficult to treat is generated is avoided. The preparation process has a simple process, is good for environment protection, is low in cost and is suitable for industrial large-scale production.
9α-dehalogenation process
-
, (2008/06/13)
The present invention involves improved processes for the dehalogenation of 9α-halosteroids (I) STR1 to produce the corresponding 11β-hydroxy steroids (II) STR2 which are known to be useful as pharmaceutical, where the improvements comprise (1) adding the 9α-halo steroid (I) to the chromium and (2) using catalytic amounts of chromium in the presence of a means of converting chromium (II) to chromium (III).
