CID 11902930

Base Information

• Chemical Name: CID 11902930
• CAS No.: 20488-27-1
• Molecular Formula: C10H18 N2 O3
• Molecular Weight: 214.26
• Hs Code.: 2933990090
• Mol file: 20488-27-1.mol

Synonyms:

Chemical Property of CID 11902930

Chemical Property:

• Vapor Pressure: 2.15E-09mmHg at 25°C
• Boiling Point: 451.1°Cat760mmHg
• Flash Point: 226.6°C
• PSA: 78.43000
• Density: 1.15g/cm³
• LogP: 0.68350
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 214.13174244
• Heavy Atom Count: 15
• Complexity: 260

Purity/Quality:

95% ^*data from raw suppliers

(2S)-1-[(2S)-2-AMINO-3-METHYLBUTANOYL]PYRROLIDINE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)N1CCCC1C(=O)[O-])[NH3+]
• Isomeric SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)[O-])[NH3+]

Technology Process of CID 11902930

There total 9 articles about CID 11902930 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butyloxycarbonyl)-L-valyl-L-proline (23361-28-6) → (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (20488-27-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1016/j.jphotobiol.2012.12.009

Reference yield:

Fmoc-Val-OH (68858-20-8) + L-proline methyl ester monohydrochloride (2133-40-6) → (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (20488-27-1)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

DOI:10.1021/acs.jafc.1c07659

Reference yield:

Fmoc-Val-Pro-OH (109425-49-2) → (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (20488-27-1)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 0.5h;

DOI:10.1021/bi100897u

upstream raw materials:

2-bromo-3-methyl-butyryl bromide

L-proline

N-benzyloxycarbonyl-L-valyl-L-proline

Fmoc-Val-Pro-OH

Downstream raw materials:

cyclo-L-prolyl-L-valine

Z-Tyr-Val-Pro-OPFP

Z-Tyr-Val-Pro-OH

benzoyl-L-valyl-L-proline methyl ester