(1S)-1,2-Dimethyl-2-hydroxypropylamine, (2S)-2-Amino-3-hydroxy-3-methylbutane

Base Information

• Chemical Name: (1S)-1,2-Dimethyl-2-hydroxypropylamine, (2S)-2-Amino-3-hydroxy-3-methylbutane
• CAS No.: 74608-26-7
• Molecular Formula: C5H13NO
• Molecular Weight: 103.164
• Hs Code.: 2922199090
• Mol file: 74608-26-7.mol

Synonyms:(3S)-3-AMINO-2-METHYLBUTAN-2-OL;(S)-3-AMINO-2-METHYLBUTAN-2-OL;

Chemical Property of (1S)-1,2-Dimethyl-2-hydroxypropylamine, (2S)-2-Amino-3-hydroxy-3-methylbutane

Chemical Property:

• Boiling Point: 178.2±13.0 °C(Predicted)
• PKA: 13.01±0.50(Predicted)
• PSA: 46.25000
• Density: 0.915±0.06 g/cm3(Predicted)
• LogP: 0.80480

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-Amino-2-methylbutan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-1,2-Dimethyl-2-hydroxypropylamine, (2S)-2-Amino-3-hydroxy-3-methylbutane

There total 8 articles about (1S)-1,2-Dimethyl-2-hydroxypropylamine, (2S)-2-Amino-3-hydroxy-3-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

((S)-2-hydroxy-1,2-dimethyl-propyl)carbamic acid tert-butyl ester (449811-20-5) → (1S)-2-hydroxy-1,2-dimethylpopylamine (74608-26-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 98.0%

(S)-3-(dibenzylamino)-2-methylbutan-2-ol (1539314-81-2) → (1S)-2-hydroxy-1,2-dimethylpopylamine (74608-26-7)

Guidance literature:

With 10 weight% Pd/C; hydrogen; In methanol; at 20 ℃; under 3361.55 Torr;

Reference yield: 53.0%

(S)-alanine ethyl ester hydrochloride (1115-59-9) + methyl iodide (74-88-4) → (1S)-2-hydroxy-1,2-dimethylpopylamine (74608-26-7)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In diethyl ether; butan-1-ol;

upstream raw materials:

methyl magnesium iodide

L-Alanine ethyl ester

3-amino-2-methylbutan-2-ol

((S)-2-hydroxy-1,2-dimethyl-propyl)carbamic acid tert-butyl ester

Downstream raw materials:

S-3-[4-(4-fluoro-phenylamino)-pyrimidin-2-ylamino]-2-methyl-butan-2-ol

(S)-2-Methyl-3-(4-phenylamino-pyrimidin-2-ylamino)-butan-2-ol

(S)-3-[4-(4-Methoxy-phenylamino)-pyrimidin-2-ylamino]-2-methyl-butan-2-ol

C₃₆H₃₉N₃O₄

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