749269-73-6

Basic information

• Product Name: 1-(4-BroMo-3-fluorophenyl)cyclopropane-1-carbonitrile
• Synonyms: 1-(4-BroMo-3-fluorophenyl)cyclopropane-1-carbonitrile;1-(4-BroMo-3-fluorophenyl)cyclopropanecarbonitrile, 96%
• CAS NO: 749269-73-6
• Molecular Formula: C₁₀H₇BrFN
• Molecular Weight: 240.0716832
• Mol File: 749269-73-6.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BroMo-3-fluorophenyl)cyclopropane-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BroMo-3-fluorophenyl)cyclopropane-1-carbonitrile(749269-73-6)
• EPA Substance Registry System: 1-(4-BroMo-3-fluorophenyl)cyclopropane-1-carbonitrile(749269-73-6)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 749269-73-6(Hazardous Substances Data)

Usage

General Description

1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carbonitrile is a specialized chemical compound. Its unique structure consists of a bromine and a fluorine atom both attached to a phenyl group, which is further attached to a cyclopropane ring bonded with a carbonitrile group. This chemical is commonly used in research and development in chemistry labs and institutions. Though its specific applications may vary, often compounds such as these are utilized as building blocks for more complex molecules in pharmaceutical or other chemical manufacturing. Safety precautions must be followed while using it due to its reactive nature.

Upstream product

• 1240286-88-7 4-Bromo-3-fluorobenzyl methanesulfonate 
• 222978-01-0 4-bromo-3-fluorobenzyl alcohol 
• 499983-13-0 2-( 4-bromo-3-fluorophenyl)acetonitrile 
• 96-49-1 [1,3]-dioxolan-2-one 
• 1072-53-3 ethyleneglycol sulfate 
• 107-04-0 1-Bromo-2-chloroethane 
• 452-74-4 4-bromo-3-fluorotoluene 
• 127425-73-4 1-bromo-4-(bromomethyl)-2-fluorobenzene 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1200722-63-9 1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanenitrile 
• 1403395-87-8 (3-{1-[3-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl)methanol 
• 1403396-91-7 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[3-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-31-2 {3-[1-(3-fluoro-4-pyridin-3-ylphenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-35-9 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(3-fluoro-4-pyridin-3-ylphenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-30-1 {3-[1-(2-fluorobiphenyl-4-yl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-34-8 3-[1-(4-bromo-3-fluorophenyl)cyclopropyl]-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403396-32-6 1-(4-bromo-3-fluorophenyl)cyclopropanecarbohydrazide 
• 1279101-06-2 2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate 
• 1279101-03-9 2-(nitrooxy)ethyl 1-(2-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1279100-99-0 2-(nitrooxy)ethyl 1-(2-fluorobiphenyl-4-yl)cyclopropanecarboxylate 
• 1279100-97-8 2-bromoethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate 
• 1279100-93-4 2-bromoethyl 1-(2-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1279100-92-3 2-bromoethyl 1-(2-fluorobiphenyl-4-yl)cyclopropanecarboxylate 

Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate

A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl diphenyl sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atmosphere, or alkali bases.

Cyclopropanation of substituted phenylacetonitriles or phenyl acetates

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is -CN or -COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O- and R1S- wherein R1 is C1-C4 straight or branched alkyl chain.