N-(2-bromophenyl)-3,4-dimethoxybenzamide

Base Information

• Chemical Name: N-(2-bromophenyl)-3,4-dimethoxybenzamide
• CAS No.: 75113-82-5
• Molecular Formula: C15H14BrNO3
• Molecular Weight: 336.185
• DSSTox Substance ID: DTXSID001275971
• Nikkaji Number: J1.008.177G
• Mol file: 75113-82-5.mol

Synonyms:N-(2-bromophenyl)-3,4-dimethoxybenzamide;Cambridge id 5260743;CBDivE_013807;DTXSID001275971;STK412698;AKOS000178084;AB00077363-01;AG-690/10352019;Z27784895;75113-82-5

Chemical Property of N-(2-bromophenyl)-3,4-dimethoxybenzamide

Chemical Property:

• PSA: 47.56000
• LogP: 3.79160
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 335.01571
• Heavy Atom Count: 20
• Complexity: 326

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2Br)OC

Technology Process of N-(2-bromophenyl)-3,4-dimethoxybenzamide

There total 10 articles about N-(2-bromophenyl)-3,4-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

Veratric acid (93-07-2) + m-Bromoaniline (591-19-5) → N-(2-bromophenyl)-3,4-dimethoxybenzamide (75113-82-5)

Guidance literature:

With ethyl phosphate; at 170 ℃; for 1h;

Reference yield: 42.0%

Veratric acid (93-07-2) + 2-bromoaniline (615-36-1) → N-(2-bromophenyl)-3,4-dimethoxybenzamide (75113-82-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2007.08.013

Reference yield: 36.0%

ortho-bromophenyl isocyanide (183209-26-9) + 2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) → N-(2-bromophenyl)-3,4-dimethoxybenzamide (75113-82-5)

Guidance literature:

With isopentyl nitrite; In 1,4-dioxane; water; 1,2-dichloro-ethane; for 0.5h; Heating;

DOI:10.1021/jo980929q

upstream raw materials:

Veratric acid

m-Bromoaniline

2-bromo-N-(3,4-dimethoxybenzylidene)aniline

2-bromo-N-(3,4-dimethoxybenzylidene)aniline N-oxide

Downstream raw materials:

2-(3,4-dimethoxyphenyl)-1,3-benzoxazole

2-(3¹,4¹-dimethoxyphenyl)quinazol-4-one

8,9-dimethoxyphenanthridin-6(5H)-one