1,4-Ditosylpiperazine

Base Information

• Chemical Name: 1,4-Ditosylpiperazine
• CAS No.: 17046-84-3
• Molecular Formula: C18H22 N2 O4 S2
• Molecular Weight: 394.516
• Hs Code.: 2933599090
• Mol file: 17046-84-3.mol

Synonyms:Piperazine,1,4-bis(p-tolylsulfonyl)- (6CI,7CI,8CI); 1,4-Bis(p-toluenesulfonyl)piperazine;1,4-Bis[(4-methylphenyl)sulfonyl]piperazine;1,4-Di-p-toluenesulfonylpiperazine; N,N'-Ditosylpiperazine; NSC 37244

Chemical Property of 1,4-Ditosylpiperazine

Chemical Property:

• Boiling Point: 565.8°Cat760mmHg
• Flash Point: 296°C
• PSA: 91.52000
• Density: 1.334g/cm³
• LogP: 4.03600
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

1,4-Ditosylpiperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Ditosylpiperazine

There total 14 articles about 1,4-Ditosylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ditosylethylenediamine (4403-78-5) + 2-bromoethyl p-toluenesulfonate (19263-21-9) → 1,4-bis-(toluene-4-sulfonyl)-piperazine (17046-84-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/c39850000918

Reference yield: 82.0%

N,N'-di(p-toluenesulfonyl)-N-[2-[(o-nitrophenyl)(p-toluenesulfonyl)amino]ethyl]-1,2-ethylenediamine (1243273-34-8) → 1,4-bis-(toluene-4-sulfonyl)-piperazine (17046-84-3)

Guidance literature:

With potassium phosphate; In N,N-dimethyl-formamide; at 150 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ol101541p

Reference yield: 52.0%

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide (16695-22-0) + sodium p-toluenesulfonamide (18522-92-4) → 1,4-bis-(toluene-4-sulfonyl)-piperazine (17046-84-3) + cyclen tetratosylate (52667-88-6)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; microwave irradiation;

DOI:10.1080/15459620500408850

upstream raw materials:

piperazine

p-toluenesulfonyl chloride

N-(2-chloroethyl)-4-methyl-N-(2-((4-methylphenyl)sulfonamido)ethyl)benzenesulfonamide

2-chloroethyl tosylate

Downstream raw materials:

piperazine