2,2-Dimethoxy-1-benzofuran-3(2H)-one

Base Information

Chemical Name:2,2-Dimethoxy-1-benzofuran-3(2H)-one
CAS No.:75335-04-5
Molecular Formula:C₁₀H₁₀O₄
Molecular Weight:194.187
Hs Code.:
DSSTox Substance ID:DTXSID70503598
Wikidata:Q82357553

Synonyms:75335-04-5;2,2-Dimethoxy-1-benzofuran-3(2H)-one;DTXSID70503598

Suppliers and Price of 2,2-Dimethoxy-1-benzofuran-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Dimethoxy-1-benzofuran-3(2H)-one

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:194.05790880
Heavy Atom Count:14
Complexity:234

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1(C(=O)C2=CC=CC=C2O1)OC

Technology Process of 2,2-Dimethoxy-1-benzofuran-3(2H)-one

There total 3 articles about 2,2-Dimethoxy-1-benzofuran-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 67-56-1
methanol

: (Z)-3-Hydroxy-1-(2-hydroxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propenone

: 67858-30-4
2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one

: 75335-04-5
3(2H)-2,2-dimethoxybenzofuran-2,3-dione

: 75349-19-8
2-Methoxy-2-(3,4,5-trimethoxybenzoyl)-3(2H)-benzofuranon

Guidance literature:: With thallium(III) nitrate; for 0.333333h; Ambient temperature;

Reference yield:

: 118-61-6
2-hydroxy-benzoic acid ethyl ester

: 75335-04-5
3(2H)-2,2-dimethoxybenzofuran-2,3-dione

: 235792-38-8,183173-94-6
methyl 2-hydroxymandelate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dichloromethane; mineral oil; hexane / 0 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -40 - -20 °C / Inert atmosphere

2.2: -78 - 25 °C / Inert atmosphere

3.1: mercury dichloride; mercury(II) oxide / water / 3.5 h / 83 - 85 °C / Inert atmosphere

With n-butyllithium; sodium hydride; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; hexane; dichloromethane; water; mineral oil;
DOI:10.1021/acs.joc.5b02350

Reference yield:

: 179538-97-7
2-trifluoromethylsulfonyloxybenzoic acid ethyl ester

: 75335-04-5
3(2H)-2,2-dimethoxybenzofuran-2,3-dione

: 235792-38-8,183173-94-6
methyl 2-hydroxymandelate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -40 - -20 °C / Inert atmosphere

1.2: -78 - 25 °C / Inert atmosphere

2.1: mercury dichloride; mercury(II) oxide / water / 3.5 h / 83 - 85 °C / Inert atmosphere

With n-butyllithium; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; hexane; water;
DOI:10.1021/acs.joc.5b02350