4-(4-CHLOROPHENYL)-2-METHYL-3-BUTYN-2-OL

Base Information

• Chemical Name: 4-(4-CHLOROPHENYL)-2-METHYL-3-BUTYN-2-OL
• CAS No.: 75373-70-5
• Molecular Formula: C11H11ClO
• Molecular Weight: 194.661
• Mol file: 75373-70-5.mol

Synonyms:2-methyl-4-(4'-chloro)phenyl-3-butyn-2-ol;1-(4-chlorophenyl)-3-methyl-1-butyn-3-ol;4-(4-chlorophenyl)-2-methylbut-3-yn-2-ol;4-(4-chlorophenyl)-2-methyl-3-butyn-2-ol;2-methyl-4-(4'-chlorophenyl)-3-butyn-2-ol;

Chemical Property of 4-(4-CHLOROPHENYL)-2-METHYL-3-BUTYN-2-OL

Chemical Property:

• PSA: 20.23000
• LogP: 2.46240

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Chloro-phenyl)-2-methyl-but-3-yn-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-CHLOROPHENYL)-2-METHYL-3-BUTYN-2-OL

There total 5 articles about 4-(4-CHLOROPHENYL)-2-METHYL-3-BUTYN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

bromochlorobenzene (106-39-8) + 2-methyl-but-3-yn-2-ol (115-19-5) → 1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol (75373-70-5)

Guidance literature:

With diisopropylammonium bromide; tri tert-butylphosphoniumtetrafluoroborate; copper(l) iodide; sodium tetrachloropalladate(II); In various solvent(s); at 80 ℃; for 20h;

DOI:10.1002/adsc.200505095

Reference yield: 92.0%

4-n-chlorophenylacetylene (873-73-4) + acetone (67-64-1) → 1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol (75373-70-5)

Guidance literature:

4-n-chlorophenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

acetone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02283

Reference yield: 87.0%

→ 1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol (75373-70-5)

Guidance literature:

upstream raw materials:

4-n-chlorophenylacetylene

acetone

phenylacetylene

2-methyl-but-3-yn-2-ol

Downstream raw materials:

4-n-chlorophenylacetylene

3-bromo-4,6-di(4-chlorophenyl)-[1,2]-oxathiine 2,2-dioxide

4,6-di(4-chlorophenyl)-3-(phenylethynyl)-1,2-oxathiine 2,2-dioxide

4,6-di(4-chlorophenyl)-[1,2]-oxathiine 2,2-dioxide