3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

Base Information

Chemical Name:3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol
CAS No.:1611477-66-7
Molecular Formula:C₁₇H₂₃B₂ClO₄
Molecular Weight:348.442
Hs Code.:

Synonyms:3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

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Chemical Property of 3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

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Technology Process of 3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

There total 3 articles about 3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 17763-67-6
Phenyl triflate

: 73183-34-3
bis(pinacol)diborane

: 75373-70-5
1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol

: 1611477-66-7
3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; palladium diacetate; In tetrahydrofuran; at 70 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b01225

Reference yield: 73.0%

: 73183-34-3
bis(pinacol)diborane

: 75373-70-5
1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol

: 1611477-66-7
3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

Guidance literature:: 1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

bis(pinacol)diborane; In tetrahydrofuran; hexane; at 75 ℃; for 24h; chemoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja5036754

Reference yield: 62.0%

: 17763-67-6
Phenyl triflate

: 73183-34-3
bis(pinacol)diborane

: 75373-70-5
1-(4-Chlorophenyl)-3-methyl-1-butyn-3-ol

: 1611477-66-7
3-(4-chlorophenyl)-5,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxaborol-2(5H)-ol

: (E)-4-(4-chlorophenyl)-2-methyl-4-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-ol

: C₁₇H₂₄BClO₃

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; lithium hexamethyldisilazane; In tetrahydrofuran; at 70 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b01225