3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- iodopyridin-2-aMine

Base Information

Chemical Name:3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- iodopyridin-2-aMine
CAS No.:756520-48-6
Molecular Formula:C13H10Cl2FIN2O
Molecular Weight:427.044
Hs Code.:
Mol file:756520-48-6.mol

Synonyms:3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-iodopyridin-2-ylamine;5-iodo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine;5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine;

Suppliers and Price of 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- iodopyridin-2-aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- iodopyridin-2-aMine

Chemical Property:

PSA：48.14000
LogP:5.43550

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- iodopyridin-2-aMine

There total 5 articles about 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- iodopyridin-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 756520-67-9,877397-71-2
(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

: 756520-48-6
5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Guidance literature:: (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine; With N-iodo-succinimide; In acetic acid; acetonitrile; at 20 ℃; for 4h;

With sodium metabisulfite; In water; acetic acid; acetonitrile;

Reference yield: 50.0%

: 756503-69-2,1448326-33-7,877399-00-3
(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine

: 756520-48-6
5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Guidance literature:: With N-iodo-succinimide; acetic acid; In acetonitrile; at 20 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 756520-66-8
1-(2,6-dichloro-3-fluorophenyl)ethanol

: 756520-48-6
5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

2: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux

3: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere

With N-iodo-succinimide; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; acetic acid; toluene; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jm2007613