3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Base Information

• Chemical Name: 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
• CAS No.: 756521-08-1
• Molecular Formula: C13H9Cl2FN2O3
• Molecular Weight: 331.13
• Mol file: 756521-08-1.mol

Synonyms:3-(2,6-dichloro-3-fluoro-benzyloxy)-2-nitro-pyridine;I14-9765;3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-nitro-pyridine;

Chemical Property of 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Chemical Property:

• PSA: 67.94000
• LogP: 5.09890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

There total 3 articles about 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxy-2-nitropyridine (15128-82-2) + 1-(2,6-dichloro-3-fluorophenyl)ethanol (756520-66-8) → (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (756521-08-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

3-hydroxy-2-nitropyridine (15128-82-2) + 1-(2,6-dichloro-3-fluorophenyl)ethyl methanesulfonate (1229457-91-3) → (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (756521-08-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

Reference yield:

2',6'-dichloro-3'-fluoroacetophenone (290835-85-7) → (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (756521-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; 2.1: Mitsunobu reaction;

DOI:10.1021/jm2007613

upstream raw materials:

3-hydroxy-2-nitropyridine

1-(2,6-dichloro-3-fluorophenyl)ethanol

2',6'-dichloro-3'-fluoroacetophenone

1-(2,6-dichloro-3-fluorophenyl)ethyl methanesulfonate

Downstream raw materials:

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine