756520-66-8

Basic information

• Product Name: 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL
• Synonyms: 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL;1-(2,6-Dichloro-3-Fluorophenyl)ethano-1-ol;1-(2,6-Dichloro-3-fluorophenyl)ethan-1-ol;2,6-Dichloro-3-fluoro-alpha-methylbenzyl alcohol;BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-;1-(2,6-Dichloro-3-Fluorophenyl)ethano-1-ol(HCl forM)
• CAS NO: 756520-66-8
• Molecular Formula: C₈H₇Cl₂FO
• Molecular Weight: 209.04
• Mol File: 756520-66-8.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 261.3±35.0℃ (760 Torr)
• Flash Point: 111.8±25.9℃
• Appearance: /
• Density: 1.406±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.30±0.20(Predicted)
• CAS DataBase Reference: 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL(756520-66-8)
• EPA Substance Registry System: 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL(756520-66-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 756520-66-8(Hazardous Substances Data)

Usage

General Description

1-(2,6-Dichloro-3-fluorophenyl)ethanol is a chemical compound with the molecular formula C8H7Cl2FO. It is a colorless to pale yellow liquid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-(2,6-Dichloro-3-fluorophenyl)ethanol is derived from chlorobenzene and is used in the preparation of insecticides, fungicides, and other agricultural chemicals. It can also be used as a solvent or as a raw material in the manufacture of various products. Due to its potential hazards and toxicity, proper handling and safety precautions are required when working with this chemical.

InChI:InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3

Upstream product

• 178813-77-9 2,6-dichloro-3-fluorobenzaldehyde 
• 1435-48-9 1,3-dichloro-4-fluorobenzene 
• 50-99-7 D-glucose 
• 290835-85-7 2',6'-dichloro-3'-fluoroacetophenone 

Downstream Products

• 1175303-65-7 7-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-(1-piperidin-4-yl-1H-pyrazol-4-yl)-furo[3,2-c]pyridin-6-ylamine 
• 1175296-53-3 3-Bromo-7-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-nitrofuro[3,2-c]-pyridine 
• 1175300-07-8 3-bromo-7-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-6-ylamine 
• 1227611-80-4 5-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridine 
• 877397-67-6 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate 
• 1201916-65-5 C₃₂H₃₇Cl₂FN₆O₇ 
• 1201916-81-5 C₃₀H₃₃Cl₂FN₄O₇ 
• 1201916-40-6 (6-amino-5-((2,6-dichIoro-3-fluorophenyl)ethoxy)pyridazin-3-yI)-N-(6-(morpholin-4-yl)pyridin-3-yl)carboxamide 
• 1201916-50-8 (6-amino-5-((2,6-dichIoro-3-fluorophenyl)ethoxy)pyridazin-3-yl)-N-(4-methoxyphenyl)carboxamide 
• 1040376-94-0 6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide 
• 877397-65-4 (S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol 
• 877397-70-1 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-nitropyridine 
• 877399-52-5 crizotinib 
• 1428476-86-1 4-(4-{6-amino-5-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR

A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.

Preparation method of deuterated crizotinib and derivatives thereof

The invention relates to a preparation method of deuterated crizotinib and derivatives thereof, and belongs to the technical field of synthesis of medical compounds. Four deuterated crizotinib with different configurations are synthesized, the influence of the deuterated position and different chirality of the deuterated crizotinib on the biological activity and the drug metabolism property of thecrizotinib is investigated, and the result shows that the deuterated crizotinib and the crizotinib have similar anti-cancer activity. Compared with a deuterated crizotinib raceme and crizotinib, thedeuterated crizotinib has certain physicochemical property advantages, has good anticancer application prospects, and provides a new compound for synthesis of novel antitumor drugs. The resolution ofthe racemate phenylethanol derivative is a key step for synthesizing the deuterated crizotinib, the ee value of the racemate phenylethanol derivative directly influences the ee value of a final product, and the resolution method has the characteristics of easiness in operation, low cost and the like.

Design, synthesis and structure-activity relationship study of aminopyridine derivatives as novel inhibitors of Janus kinase 2

Janus Kinase 2 (JAK2) is a kind of intracellular non-receptor protein tyrosine kinase and has been certified as an important target for the treatment of myeloproliferative neoplasms and rheumatoid arthritis. However, the low selectivity and potential safety issues restrict the clinical applications of JAK2 inhibitors. Here we found that crizotinib showed good inhibitory activity against JAK2 by enzymatic assays (IC50 = 27 nM). Then we carried out structure-based drug design and synthesized a series of compounds with an aminopyridine scaffold. Finally, compound 12k and 12l were identified as the promising inhibitors of JAK2, which exhibited high inhibitory activity (IC50 = 6 nM and 3 nM, respectively) and selectivity for JAK2 over JAK1 and JAK3, and showed potent antiproliferative activities toward HEL human erythroleukemia cells. Moreover, 12k suppressed symptoms of the collagen-induced arthritis (CIA) model in rats.