THYMOPOIETIN II (33-36)

Base Information

• Chemical Name: THYMOPOIETIN II (33-36)
• CAS No.: 75957-56-1
• Molecular Formula: C24H37N5O8
• Molecular Weight: 523.586
• Mol file: 75957-56-1.mol

Synonyms:Thymopoietin II (33-36), (Des-Arg1)-Thymopentin;Thymopoietin II (33-36);

Chemical Property of THYMOPOIETIN II (33-36)

Chemical Property:

• PSA: 234.17000
• LogP: 1.63400
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of THYMOPOIETIN II (33-36)

There total 8 articles about THYMOPOIETIN II (33-36) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Val-OH (68858-20-8) + Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + N-α-(9-fluorenylmethyloxycarbonyl)-N-ω′,N-ω″-bis-tert-butyloxycarbonyl-L-argine (143824-77-5) → thymopentin (69558-55-0) + H-Lys-Asp-Val-Tyr-OH (75957-56-1)

Guidance literature:

Fmoc-Tyr(tBu)-OH; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; for 1h; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; for 0.5h; solid phase reaction;

Fmoc-Val-OH; Fmoc-(tBu)Asp-OH; Fmoc-Lys(tert-butoxycarbonyl); N-α-(9-fluorenylmethyloxycarbonyl)-N-ω′,N-ω″-bis-tert-butyloxycarbonyl-L-argine; Further stages;

DOI:10.1021/op1001403

Reference yield:

Nα-t-butoxycarbonyl-Nε-benzyloxycarbonyl-L-lysyl-β-benzyl-L-aspartyl-L-valyl-L-tyrosine benzyl ester (75957-55-0) → H-Lys-Asp-Val-Tyr-OH (75957-56-1)

Guidance literature:

With methyl-phenyl-thioether; hydrogen fluoride; methoxybenzene; ortho-cresol; for 0.5h; ice bath;

DOI:10.1248/cpb.28.2507

Reference yield:

t-Boc-L-valine (13734-41-3) → H-Lys-Asp-Val-Tyr-OH (75957-56-1)

Guidance literature:

Multi-step reaction with 6 steps

1: HOBT, dicyclohexylcarbodiimide

2: TFA-anisole

3: HOBT-dicyclohexylcarbodiimide

4: TFA-anisole

5: HOBT-dicyclohexylcarbodiimide

6: HF, anisole-thioanisole-o-cresol / 0.5 h / ice bath

With methyl-phenyl-thioether; TFA-anisole; hydrogen fluoride; benzotriazol-1-ol; methoxybenzene; ortho-cresol; dicyclohexyl-carbodiimide;

DOI:10.1248/cpb.28.2507

upstream raw materials:

N^α-t-butoxycarbonyl-N^ε-benzyloxycarbonyl-L-lysyl-β-benzyl-L-aspartyl-L-valyl-L-tyrosine benzyl ester

t-Boc-L-valine

H-Val-Tyr-OBzl

L-tyrosine benzyl ester p-toluenesulfonate

Refernces

• 1、 Abiko,Onodera,Sekino. "The effect of thymopoietin II fragments and their analogs on E-rosette forming cells in the uremic state". . p. 2507 - 2511. Retrieved 2007/10/02.