Technology Process of Cyclobutanol, 2-(1-cyclohexen-1-yl)-, (1R,2R)-rel-
There total 17 articles about Cyclobutanol, 2-(1-cyclohexen-1-yl)-, (1R,2R)-rel- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminum isopropoxide;
In
isopropyl alcohol;
for 22h;
Heating;
DOI:10.1021/ja00547a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C
2: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C
3: 83 percent / DIBAL-H / hexane; tetrahydrofuran / -78 °C
4: 60 percent / 48percent fluoboric acid / diethyl ether / 1.17 h
5: 1.) K-Selectride, 2.) 30percent aq. hydrogen peroxide, 20percent aq. sodium hydroxide / 1.) ether, 30 min, 2.) 30 min
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; tetrafluoroboric acid; dihydrogen peroxide; diisobutylaluminium hydride; potassium tri-sec-butyl-borohydride; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja00547a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C
2: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C
3: 83 percent / DIBAL-H / hexane; tetrahydrofuran / -78 °C
4: 60 percent / 48percent fluoboric acid / diethyl ether / 1.17 h
5: 98 percent / aluminium isopropoxide / propan-2-ol / 22 h / Heating
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrafluoroboric acid; aluminum isopropoxide; diisobutylaluminium hydride; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; hexane; isopropyl alcohol;
DOI:10.1021/ja00547a015
