AKOS BBS-00001121

Base Information

• Chemical Name: AKOS BBS-00001121
• CAS No.: 77377-07-2
• Molecular Formula: C13H11NO
• Molecular Weight: 197.236
• Hs Code.: 2933399090
• Mol file: 77377-07-2.mol

Synonyms:E-2-p-hydroxystyrylpyridine;

Chemical Property of AKOS BBS-00001121

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 350.934oC at 760 mmHg
• Flash Point: 166.039oC
• PSA: 33.12000
• Density: 1.2g/cm3
• LogP: 2.95760

Purity/Quality:

98% ^*data from raw suppliers

4-[2-(2-Pyridinyl)vinyl]phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AKOS BBS-00001121

There total 7 articles about AKOS BBS-00001121 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(4-Methoxy-styryl)-pyridin (19036-99-8) → (E)-4-(2-(pyridin-2-yl)vinyl)phenol (77377-07-2)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1007/s00044-018-2150-8

Reference yield:

α-picoline (109-06-8) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (E)-4-(2-(pyridin-2-yl)vinyl)phenol (77377-07-2)

Guidance literature:

With acetic anhydride; und Erhitzen mit Wasser auf 140grad;

Reference yield:

diethyl 4-methoxybenzylphosphonate (1145-93-3) → (E)-4-(2-(pyridin-2-yl)vinyl)phenol (77377-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / dimethylformamide; ethanol / 3 h / 20 °C

2: BBr₃ / CH₂Cl₂ / -10 - 0 °C

With sodium ethanolate; boron tribromide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.53.1587

upstream raw materials:

α-picoline

4-hydroxy-benzaldehyde

2-(4-Methoxy-styryl)-pyridin

diethyl 4-methoxybenzylphosphonate

Downstream raw materials:

1-ethyl-2-(4-hydroxy-styryl)-pyridinium; iodide

(E)-1-methyl-2-[4-(hydroxybenzyl)-vinyl]-pyridinium iodide

4-(2-[2]pyridyl-ethyl)-phenol