3'-Adenylic acid, N-benzoyl-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, mono(2-chlorophenyl) ester, 5'-[2-(dibromomethyl)benzoate], compd. with N,N-diethylethanamine (1:1)

Base Information

• Chemical Name: 3'-Adenylic acid, N-benzoyl-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, mono(2-chlorophenyl) ester, 5'-[2-(dibromomethyl)benzoate], compd. with N,N-diethylethanamine (1:1)
• CAS No.: 77451-40-2
• Molecular Formula: C₆H₁₅N*C₃₇H₃₅Br₂ClN₅O₁₁P
• Molecular Weight: 1053.14

Synonyms:

Chemical Property of 3'-Adenylic acid, N-benzoyl-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, mono(2-chlorophenyl) ester, 5'-[2-(dibromomethyl)benzoate], compd. with N,N-diethylethanamine (1:1)

Chemical Property:

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Technology Process of 3'-Adenylic acid, N-benzoyl-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, mono(2-chlorophenyl) ester, 5'-[2-(dibromomethyl)benzoate], compd. with N,N-diethylethanamine (1:1)

There total 7 articles about 3'-Adenylic acid, N-benzoyl-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, mono(2-chlorophenyl) ester, 5'-[2-(dibromomethyl)benzoate], compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2,6-dihydropyran (17327-22-9) → N6-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)-5'-O-adenosine 3'-<(o-chlorophenyl)triethylammonium phosphate> (77451-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 1) toluene-p-sulphonic acid monohydrate, 2) methanolic ammonia / dioxane / 2 h / 20 °C

With ammonia; toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.1016/0040-4020(80)88035-5

Reference yield:

o-di-bromomethyl-benzoyl chloride (73407-51-9) → N6-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)-5'-O-adenosine 3'-<(o-chlorophenyl)triethylammonium phosphate> (77451-40-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 77 percent / 1) toluene-p-sulphonic acid monohydrate, 2) methanolic ammonia / dioxane / 2 h / 20 °C

With ammonia; toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.1016/0040-4020(80)88035-5

Reference yield:

2',3'-di-O-methoxymethylidene-6-N-benzoyladenosine (65978-10-1) → N6-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)-5'-O-adenosine 3'-<(o-chlorophenyl)triethylammonium phosphate> (77451-40-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 77 percent / 1) toluene-p-sulphonic acid monohydrate, 2) methanolic ammonia / dioxane / 2 h / 20 °C

With ammonia; toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.1016/0040-4020(80)88035-5

upstream raw materials:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

5'-O-(o-dibromomethylbenzoyl)-2'-O-methoxytetrahydropyranyl-6-N-benzoyladenosine

triethylamine

4-methoxy-2,6-dihydropyran

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