4,4'-[(PhenylMethyl)iMino]bisbutanenitrile

Base Information

• Chemical Name: 4,4'-[(PhenylMethyl)iMino]bisbutanenitrile
• CAS No.: 78217-67-1
• Molecular Formula: C15H19N3
• Molecular Weight: 241.336
• Mol file: 78217-67-1.mol

Synonyms:N-benzyl-5-aza-nonanedinitrile;4,4'-[(Phenylmethyl)imino]bisbutanenitrile;1,7-dicyano-N-benzyl-4-azaheptane;5-benzyl-5-azanonanedinitrile;

Chemical Property of 4,4'-[(PhenylMethyl)iMino]bisbutanenitrile

Chemical Property:

• PSA: 50.82000
• LogP: 3.09616
• Solubility.: DCM, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

4,4''-[(Phenylmethyl)imino]bisbutanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,4''-[(Phenylmethyl)imino]bisbutanenitrile is an intermediate in the synthesis of sym-Homospermidine (H625000), an analogue of Spermidine. sym-Homospermidine is used as an antineoplastic agent.

Technology Process of 4,4'-[(PhenylMethyl)iMino]bisbutanenitrile

There total 4 articles about 4,4'-[(PhenylMethyl)iMino]bisbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-Chlorobutyronitrile (628-20-6) + benzylamine (100-46-9) → N,N-Bis(3-cyanopropyl)-benzylamine (78217-67-1)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 16h; Reflux;

DOI:10.1074/jbc.M111.307835

Reference yield:

4-Chlorobutyronitrile (628-20-6) + sodium carbonate (497-19-8) + benzylamine (100-46-9) → N,N-Bis(3-cyanopropyl)-benzylamine (78217-67-1)

Guidance literature:

With Ki; In diethyl ether; chloroform; toluene; butan-1-ol;

Reference yield:

benzylamine (100-46-9) + 4-bromobutanenitrile (5332-06-9) → N,N-Bis(3-cyanopropyl)-benzylamine (78217-67-1)

Guidance literature:

With potassium carbonate; In butan-1-ol; at 115 ℃;

DOI:10.1016/S0960-894X(03)00668-1

upstream raw materials:

4-Chlorobutyronitrile

benzylamine

4-bromobutanenitrile

sodium carbonate

Downstream raw materials:

N⁵-benzyl-N¹,N⁹-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine hydrochloride

N⁵--N¹,N⁹-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine

N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine hydrobromide

N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine