(2,4-Dimethoxyphenyl)(4-methylphenyl)methanone

Base Information

Chemical Name:(2,4-Dimethoxyphenyl)(4-methylphenyl)methanone
CAS No.:78589-05-6
Molecular Formula:C16H16O3
Molecular Weight:256.301
Hs Code.:
DSSTox Substance ID:DTXSID10561713
Nikkaji Number:J3.572.340D
Wikidata:Q82445568

Synonyms:(2,4-Dimethoxyphenyl)(4-methylphenyl)methanone;78589-05-6;SCHEMBL21709893;DTXSID10561713;(2,4-Dimethoxy-phenyl)-p-tolyl-methanone

Suppliers and Price of (2,4-Dimethoxyphenyl)(4-methylphenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,4-Dimethoxyphenyl)(4-methylphenyl)methanone

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:256.109944368
Heavy Atom Count:19
Complexity:294

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)OC)OC

Technology Process of (2,4-Dimethoxyphenyl)(4-methylphenyl)methanone

There total 5 articles about (2,4-Dimethoxyphenyl)(4-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6833-18-7
4-methyl-N-phenylbenzamide

: 151-10-0
1,3-Dimethoxybenzene

: 142-04-1,36663-09-9
aniline hydrochloride

: 78589-05-6
(2,4-dimethoxyphenyl)(p-tolyl)methanone

Guidance literature:: 4-methyl-N-phenylbenzamide; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 0 ℃; for 0.166667h; Inert atmosphere;

1,3-Dimethoxybenzene; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In ethanol; for 2h; chemoselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/acs.joc.6b01647

Reference yield:

: 4-Methyl-benzoic acid 3-methoxy-phenyl ester

: 78589-05-6
(2,4-dimethoxyphenyl)(p-tolyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: Lewis acid / nitrobenzene / Heating

With Lewis acid; In nitrobenzene;
DOI:10.1016/0584-8539(81)80141-9

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 78589-05-6
(2,4-dimethoxyphenyl)(p-tolyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / dichloromethane / 0 - 23 °C / Inert atmosphere

2.1: bis(triphenylphosphine)nickel(II) chloride / diethyl ether / 0.08 h / 23 °C / Inert atmosphere; Schlenk technique

2.2: 12 h / 23 °C / Inert atmosphere; Schlenk technique

With dmap; bis(triphenylphosphine)nickel(II) chloride; triethylamine; In diethyl ether; dichloromethane; 2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1002/chem.201602202