1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one

Base Information

Chemical Name:1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one
CAS No.:78877-55-1
Molecular Formula:C₁₃H₂₁NO
Molecular Weight:207.316
Hs Code.:
DSSTox Substance ID:DTXSID80506712

Synonyms:78877-55-1;1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one;DTXSID80506712

Suppliers and Price of 1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:207.162314293
Heavy Atom Count:15
Complexity:266

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1C(=C)C(=O)N1C2CCCCC2

Technology Process of 1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one

There total 5 articles about 1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Toluene-4-sulfonic acid 1-(1-cyclohexylcarbamoyl-vinyl)-butyl ester

: 78877-55-1
1-cyclohexyl-3-methylene-4-propylazetidin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 ℃; Yield given;
DOI:10.1039/c39810000404

Reference yield:

: 78257-87-1
N-cyclohexyl-2-oxopropanamide 2,4,6-tri-iso-propylbenzenesulphonylhydrazone

: 78877-55-1
1-cyclohexyl-3-methylene-4-propylazetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-BuLi / 1) DME, 25 deg C, 2) -78 deg C, then 25 deg C

2: n-BuLi / tetrahydrofuran / 1) -78 deg C, 2) 25 deg C, 10 min

3: NaH / tetrahydrofuran / 25 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran;
DOI:10.1039/c39810000404

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 78877-55-1
1-cyclohexyl-3-methylene-4-propylazetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / triethylamine / diethyl ether / -78 °C

3: 1.) n-butyl-lithium / 1.) DME, -78 deg C -> room temperature, 60 min, room temperature 30 min, 2.) -78 deg C -> room temperature 15 min

4: 1.) n-butyl-lithium, 2.) toluene-4-sulphonic anhydride / 1.) THF, -78 deg C -> 0 deg C, 2.) -78 deg C -> room temperature

With n-butyllithium; p-toluenesulfonylanhydride; triethylamine; In diethyl ether;