Technology Process of 1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one
There total 5 articles about 1-Cyclohexyl-3-methylidene-4-propylazetidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 25 ℃;
Yield given;
DOI:10.1039/c39810000404
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) n-BuLi / 1) DME, 25 deg C, 2) -78 deg C, then 25 deg C
2: n-BuLi / tetrahydrofuran / 1) -78 deg C, 2) 25 deg C, 10 min
3: NaH / tetrahydrofuran / 25 °C
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran;
DOI:10.1039/c39810000404
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 50 percent / triethylamine / diethyl ether / -78 °C
3: 1.) n-butyl-lithium / 1.) DME, -78 deg C -> room temperature, 60 min, room temperature 30 min, 2.) -78 deg C -> room temperature 15 min
4: 1.) n-butyl-lithium, 2.) toluene-4-sulphonic anhydride / 1.) THF, -78 deg C -> 0 deg C, 2.) -78 deg C -> room temperature
With
n-butyllithium; p-toluenesulfonylanhydride; triethylamine;
In
diethyl ether;
