Benzoic acid, 4-(2-methyl-1,3-dioxolan-2-yl)-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4-(2-methyl-1,3-dioxolan-2-yl)-, methyl ester
• CAS No.: 78906-11-3
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 78906-11-3.mol

Synonyms:4-(2-Methyl-[1,3]dioxolan-2-yl)-benzoic acid methyl ester;methyl 4-(2-methyl-1,3-dioxolan-2-yl)benzoate;

Chemical Property of Benzoic acid, 4-(2-methyl-1,3-dioxolan-2-yl)-, methyl ester

Chemical Property:

• PSA: 44.76000
• LogP: 1.69270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-(2-methyl-1,3-dioxolan-2-yl)-, methyl ester

There total 2 articles about Benzoic acid, 4-(2-methyl-1,3-dioxolan-2-yl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyleneglycol vinyl ether (764-48-7) + 4-methoxycarbonylphenyl bromide (619-42-1) → methyl 4-[(1,3-dioxolan-2-yl)methyl]benzoate + 2-methyl-2-(4-methoxycarbonylphenyl)-1,3-dioxolan (78906-11-3)

Guidance literature:

With cis,cis,cis-1,2,3,4-tetrakis (diphenylphosphinomethyl)cyclopentane; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); In N,N-dimethyl-formamide; at 130 ℃; for 20h;

DOI:10.1002/ejoc.200500540

Reference yield:

methyl 4-acetylbenzoate (3609-53-8) + ethylene glycol (107-21-1) → 2-methyl-2-(4-methoxycarbonylphenyl)-1,3-dioxolan (78906-11-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 130 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02833

Reference yield: 90.85%

methylmagnesium bromide (75-16-1) + 2-methyl-2-(4-methoxycarbonylphenyl)-1,3-dioxolan (78906-11-3) → 1-(4-(2-hydroxypropan-2-yl)phenyl)ethan-1-one (54549-72-3)

Guidance literature:

methylmagnesium bromide; 2-methyl-2-(4-methoxycarbonylphenyl)-1,3-dioxolan; In tetrahydrofuran; at -5 ℃; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 2h; pH=1;

upstream raw materials:

ethyleneglycol vinyl ether

4-methoxycarbonylphenyl bromide

methyl 4-acetylbenzoate

ethylene glycol

Downstream raw materials:

2-methyl-2-(4-hydoxymethylphenyl)-1,3-dioxolyn

2-methyl-2-(4-chloromethylphenyl)-1,3-dioxolan

C₁₃H₁₇NO₄

4-(2-methyl-1,3-dioxolan-2-yl)benzaldehyde