2'-Adenylic acid, N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)

Base Information

• Chemical Name: 2'-Adenylic acid, N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)
• CAS No.: 79154-56-6
• Molecular Formula: C35H47ClN5O9PSi2.C6H15N
• Molecular Weight: 905.576
• Mol file: 79154-56-6.mol

Synonyms:

Chemical Property of 2'-Adenylic acid, N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-Adenylic acid, N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)

There total 6 articles about 2'-Adenylic acid, N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) (121768-15-8) → 3',5'-O-(1,1,3,3,-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) phosphate triethylammonium salt (79154-56-6)

Guidance literature:

With triethylamine carbonate; In tetrahydrofuran; water;

Reference yield:

1,1,3,3-tetraisopropyldisiloxane (18043-71-5) → 3',5'-O-(1,1,3,3,-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) phosphate triethylammonium salt (79154-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 g

DOI:10.1016/S0040-4039(01)90427-7

Reference yield:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N6-benzoyladenosine (79154-57-7) → 3',5'-O-(1,1,3,3,-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) phosphate triethylammonium salt (79154-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 18 h / Ambient temperature

2: 99 percent / Et₃NHCO₃ / H₂O; tetrahydrofuran

With triethylamine carbonate; In tetrahydrofuran; water;

upstream raw materials:

3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate)

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

1,1,3,3-tetraisopropyldisiloxane

Downstream raw materials:

C₅₆H₆₆ClN₁₀O₁₅PSi₂

3'-O-(1,1,3,3-tetraisopropyldisiloxane-1-yl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) (2-cyanoethyl) phosphate

adenosine

C₉₁H₁₁₃Cl₂N₁₅O₂₄P₂Si₄