2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, (2R,5R)-

Base Information

Chemical Name:2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, (2R,5R)-
CAS No.:797801-72-0
Molecular Formula:C₇H₁₃NO₃
Molecular Weight:159.185
Hs Code.:

Synonyms:(2R,5R)-5-Hydroxy-piperidine-2-carboxylic acid methyl ester;5-(R)-hydroxy-2-(R)-pipecolic acid methyl ester;

Suppliers and Price of 2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, (2R,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, (2R,5R)-

Chemical Property:

PSA：58.56000
LogP:-0.39890

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, (2R,5R)-

There total 9 articles about 2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, (2R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 448964-01-0,478409-64-2
(2R,5R)-5-hydroxypiperidine-2-carboxylic acid

: 797801-72-0,189952-46-3
methyl (2R,5R)-5-hydroxypiperidine-2-carboxylate

Guidance literature:: With hydrogenchloride; for 1.5h; Reflux;

Reference yield:

: 797801-68-4
5-(R)-hydroxy-N-benzyloxycarbonyl-2-(R)-pipecolic acid methyl ester

: 797801-72-0,189952-46-3
methyl (2R,5R)-5-hydroxypiperidine-2-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; under 3102.89 Torr;
DOI:10.1016/j.tet.2004.07.080

Reference yield:

: 6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
D-Glutamic acid

: 797801-72-0,189952-46-3
methyl (2R,5R)-5-hydroxypiperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / NaHCO₃

2: 82 percent / TsOH / benzene / Heating

3: 93 percent / NaOMe

4: Et₃N / tetrahydrofuran

5: diethyl ether

6: 52 percent / [Rh(OAc)2]2 / benzene / Heating

7: 93 percent / NaBH₄ / methanol

8: H₂ / Pd/C / 3102.89 Torr

With dirhodium tetraacetate; sodium tetrahydroborate; hydrogen; sodium methylate; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1016/j.tet.2004.07.080