8-acetyl-2-(dipropylamino)tetralin

Base Information

• Chemical Name: 8-acetyl-2-(dipropylamino)tetralin
• CAS No.: 140221-50-7
• Molecular Formula: C₁₈H₂₇NO
• Molecular Weight: 273.418
• Mol file: 140221-50-7.mol

Synonyms:(?à)-8-Acetyl-2-(dipropylamino)tetralin;LY 41

Chemical Property of 8-acetyl-2-(dipropylamino)tetralin

Chemical Property:

• Vapor Pressure: 7.74E-07mmHg at 25°C
• Boiling Point: 407.1°Cat760mmHg
• Flash Point: 145.2°C
• PSA: 20.31000
• Density: 1g/cm³
• LogP: 3.86850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-acetyl-2-(dipropylamino)tetralin

There total 7 articles about 8-acetyl-2-(dipropylamino)tetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + tetramethylstannane (594-27-4) + (+/-)-2-(dipropylaminoZ)-8-<(trifluoromethylsulfonyl)oxy>tetralin (134394-05-1) → (+/-)-8-acetyl-2-(dipropylamino)tetralin (140221-50-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2,6-di-tert-butyl-4-methyl-phenol; 4 A molecular sieve; lithium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 14h;

DOI:10.1021/jm00078a012

Reference yield:

8-hydroxy-2-(di-N-propylamino)tetralin (78950-78-4) → (+/-)-8-acetyl-2-(dipropylamino)tetralin (140221-50-7)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / CH₂Cl₂ / -78 - 0 °C

2: Et₃N, 1,1'-bis(diphenylphosphino)ferrocene, Pd(OAc)2 / dimethylsulfoxide / 48 h / 70 °C

3: aq. NaOH / methanol / Ambient temperature

4: diethyl ether / 72 h / Ambient temperature

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium hydroxide; potassium carbonate; triethylamine; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00078a012

Reference yield:

(+/-)-methyl-2-(dipropylamino)tetralin-8-carboxylate (124688-32-0) → (+/-)-8-acetyl-2-(dipropylamino)tetralin (140221-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / methanol / Ambient temperature

2: diethyl ether / 72 h / Ambient temperature

With sodium hydroxide; In methanol; diethyl ether;

DOI:10.1021/jm00078a012

upstream raw materials:

carbon monoxide

tetramethylstannane

(+/-)-2-(dipropylaminoZ)-8-<(trifluoromethylsulfonyl)oxy>tetralin

2-dipropylamino-1,2,3,4-tetrahydronaphthalene-8-carboxylic acid