3-Pyridinecarboxylic acid, 6-[[[(phenyl-2-thienylmethylene)amino]oxy]methyl]-, ethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 6-[[[(phenyl-2-thienylmethylene)amino]oxy]methyl]-, ethyl ester
• CAS No.: 800371-97-5
• Molecular Formula: C20H18N2O3S
• Molecular Weight: 366.441
• Mol file: 800371-97-5.mol

Synonyms:

Chemical Property of 3-Pyridinecarboxylic acid, 6-[[[(phenyl-2-thienylmethylene)amino]oxy]methyl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 6-[[[(phenyl-2-thienylmethylene)amino]oxy]methyl]-, ethyl ester

There total 4 articles about 3-Pyridinecarboxylic acid, 6-[[[(phenyl-2-thienylmethylene)amino]oxy]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

phenyl(thiophen-2-yl)methanone oxime (70608-22-9) + 6-(chloromethyl)-3-pyridinecarboxylic acid ethyl ester (10177-23-8) → 6-[1-Phenyl-1-thiophen-2-yl-meth-(Z)-ylideneaminooxymethyl]-nicotinic acid ethyl ester (800371-97-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1016/j.ejmech.2004.07.003

Reference yield:

Pyridine-2,5-dicarboxylic acid (100-26-5) → 6-[1-Phenyl-1-thiophen-2-yl-meth-(Z)-ylideneaminooxymethyl]-nicotinic acid ethyl ester (800371-97-5)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄

2: NaBH₄; CaCl₂

3: 94 percent / CCl₄; nBu₃P / 0.25 h

4: 74 percent / K₂CO₃ / acetonitrile / Heating

With tetrachloromethane; sodium tetrahydroborate; tributylphosphine; sulfuric acid; potassium carbonate; calcium chloride; In acetonitrile;

DOI:10.1016/j.ejmech.2004.07.003

Reference yield:

ethyl 2,5-pyridinedicarboxylate (5552-44-3) → 6-[1-Phenyl-1-thiophen-2-yl-meth-(Z)-ylideneaminooxymethyl]-nicotinic acid ethyl ester (800371-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄; CaCl₂

2: 94 percent / CCl₄; nBu₃P / 0.25 h

3: 74 percent / K₂CO₃ / acetonitrile / Heating

With tetrachloromethane; sodium tetrahydroborate; tributylphosphine; potassium carbonate; calcium chloride; In acetonitrile;

DOI:10.1016/j.ejmech.2004.07.003

upstream raw materials:

phenyl(thiophen-2-yl)methanone oxime

6-(chloromethyl)-3-pyridinecarboxylic acid ethyl ester

Pyridine-2,5-dicarboxylic acid

ethyl 2,5-pyridinedicarboxylate

Refernces