BENZO[1,3]DIOXOLE-5-CARBOXAMIDINE HYDROCHLORIDE

Base Information

• Chemical Name: BENZO[1,3]DIOXOLE-5-CARBOXAMIDINE HYDROCHLORIDE
• CAS No.: 80531-15-3
• Molecular Formula: C8H8N2O2.ClH
• Molecular Weight: 200.62200
• Hs Code.: 2932999099
• Mol file: 80531-15-3.mol

Synonyms:3,4-(methylenedioxy)phenylmethanol;piperonylamidine,hydrochloride;5-azapiperonyl alcohol;1,3-BENZODIOXOLE-5-METHANOL;Piperonylamidin,Hydrochlorid;Piperonol;5-Hydroxymethyl-1,3-benzodioxole;Benzo[d][1,3]dioxole-5-carboximidamide hydrochloride;3,4-methylendioxybenzylalcohol;Piperonyl alcohol;3,4-Methylenedioxybenzyl alcohol;Benzo[d][1,3]dioxol-5-ylmethanol;1,3-benzodioxole-5-carboximidamide hydrochloride;Helioalcohol;1-Hydroxymethyl-3,4-methylenedioxybenzene;benzo[1,3]dioxol-5-yl-methanol;

Chemical Property of BENZO[1,3]DIOXOLE-5-CARBOXAMIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 68.33000
• LogP: 2.30140

Purity/Quality:

≥95% ^*data from raw suppliers

Benzo[1,3]dioxole-5-carboxamidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZO[1,3]DIOXOLE-5-CARBOXAMIDINE HYDROCHLORIDE

There total 1 articles about BENZO[1,3]DIOXOLE-5-CARBOXAMIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperonylonitrile (4421-09-4) → benzo[1,3]dioxole-5-carboxamidine hydrochloride (80531-15-3)

Guidance literature:

piperonylonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; water; isopropyl alcohol; at -78 - 0 ℃; for 0.5h;

Reference yield: 62.0%

benzo[1,3]dioxole-5-carboxamidine hydrochloride (80531-15-3) + 6-Chloro-5-[1-chloro-1-dimethylamino-meth-(Z)-ylidene]-1-phenyl-2,3,4,5-tetrahydro-pyridinium; chloride → (2-benzo[1,3]dioxol-5-yl-8-phenyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-dimethyl-amine

Guidance literature:

In N,N-dimethyl-formamide; toluene; at 80 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.12.069

Reference yield:

ethyl 1-{[(3-ethylphenyl)amino]carbonyl}-4-oxopiperidine-3-carboxylate (1095717-40-0) + benzo[1,3]dioxole-5-carboxamidine hydrochloride (80531-15-3) → 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide (1095717-41-1)

Guidance literature:

ethyl 1-{[(3-ethylphenyl)amino]carbonyl}-4-oxopiperidine-3-carboxylate; benzo[1,3]dioxole-5-carboxamidine hydrochloride; With potassium carbonate; In methanol; at 65 ℃; for 7h;

With acetic acid; In methanol;

upstream raw materials:

piperonylonitrile

Downstream raw materials:

2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

2-(1,3-benzodioxol-5-yl)-6-{[(3-ethylphenyl)amino]carbonyl}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl 4-methylbenzenesulfonate

Refernces