2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Base Information

• Chemical Name: 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
• CAS No.: 1095717-41-1
• Molecular Formula: C₂₃H₂₂N₄O₄
• Molecular Weight: 418.452
• Mol file: 1095717-41-1.mol

Synonyms:2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Chemical Property of 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

There total 4 articles about 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 1-{[(3-ethylphenyl)amino]carbonyl}-4-oxopiperidine-3-carboxylate (1095717-40-0) + benzo[1,3]dioxole-5-carboxamidine hydrochloride (80531-15-3) → 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide (1095717-41-1)

Guidance literature:

ethyl 1-{[(3-ethylphenyl)amino]carbonyl}-4-oxopiperidine-3-carboxylate; benzo[1,3]dioxole-5-carboxamidine hydrochloride; With potassium carbonate; In methanol; at 65 ℃; for 7h;

With acetic acid; In methanol;

Reference yield:

4-piperidone-3-carboxylic acid ethyl ester (67848-59-3) → 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide (1095717-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 20 °C

2: potassium carbonate / methanol / 7 h / 65 °C

With potassium carbonate; In methanol; dichloromethane;

Reference yield:

piperonylonitrile (4421-09-4) → 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide (1095717-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 6 h / 0 - 20 °C

1.2: 0.5 h / -78 - 0 °C

2.1: potassium carbonate / methanol / 7 h / 65 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

upstream raw materials:

ethyl 1-{[(3-ethylphenyl)amino]carbonyl}-4-oxopiperidine-3-carboxylate

benzo[1,3]dioxole-5-carboxamidine hydrochloride

4-piperidone-3-carboxylic acid ethyl ester

1-ethyl-3-isocyanatobenzene

Downstream raw materials:

2-(1,3-benzodioxol-5-yl)-6-{[(3-ethylphenyl)amino]carbonyl}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl 4-methylbenzenesulfonate

2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide