Acetamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-2-[[(2R,4S,5R)-2-(4-meth oxyphenyl)-4-(2-propenyl)-1,3-dioxan-5-yl]oxy]-N-methyl-

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Chemical Name:Acetamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-2-[[(2R,4S,5R)-2-(4-meth oxyphenyl)-4-(2-propenyl)-1,3-dioxan-5-yl]oxy]-N-methyl-
CAS No.:807369-03-5
Molecular Formula:C26H33NO6
Molecular Weight:455.551
Hs Code.:

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Chemical Property of Acetamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-2-[[(2R,4S,5R)-2-(4-meth oxyphenyl)-4-(2-propenyl)-1,3-dioxan-5-yl]oxy]-N-methyl-

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Technology Process of Acetamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-2-[[(2R,4S,5R)-2-(4-meth oxyphenyl)-4-(2-propenyl)-1,3-dioxan-5-yl]oxy]-N-methyl-

There total 2 articles about Acetamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-2-[[(2R,4S,5R)-2-(4-meth oxyphenyl)-4-(2-propenyl)-1,3-dioxan-5-yl]oxy]-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 807369-69-3
[(2R,4S,5R)-4-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yloxy]-acetic acid methyl ester

: 807369-03-5
2-[(2R,4S,5R)-4-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yloxy]-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

Guidance literature:: With sodium methylate; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2004.09.160

Reference yield:

: 220256-94-0
(2R,4S,5R)-4-allyl-2-(4-methoxyphenyl)-[1,3]dioxan-5-ol

: 807369-03-5
2-[(2R,4S,5R)-4-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yloxy]-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NaH; n-Bu₄NI / tetrahydrofuran / 0 - 20 °C

2: 84 percent / NaOMe / tetrahydrofuran / 20 °C

With sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2004.09.160

Reference yield:

: 807369-03-5
2-[(2R,4S,5R)-4-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yloxy]-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

: [(Z)-(2R,3S,8R)-3-(4-Methoxy-benzyloxy)-8-((E)-propenyl)-3,4,7,8-tetrahydro-2H-oxocin-2-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1.1: LDA; LiCl / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / 0 °C

1.3: LDA; NH₃*BH₃ / tetrahydrofuran / 0 °C

2.1: 98 percent / imidazole / dimethylformamide / 20 °C

3.1: 99 percent / PhMe / Grubbs second generation ruthenium catalyst / 80 °C

4.1: 91 percent / TBAF / tetrahydrofuran / 20 °C

5.1: 81 percent / SO₃; pyridine; Et₃N / dimethylsulfoxide / 20 °C

6.1: CrCl₂; LiI / tetrahydrofuran / 20 °C

7.1: 51 percent / K₃PO₄ / Pd(PPh₃)4 / dioxane / 60 °C

8.1: 68 percent / diisobutylaluminium hydride / CH₂Cl₂ / -78 °C

9.1: 66 percent / PCC; NaOAc; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

10.1: 67 percent / KHMDS / tetrahydrofuran / -78 °C

11.1: 78 percent / mercuric acetate / tetrahydrofuran; H₂O / 20 °C

With pyridine; 1H-imidazole; chromium dichloride; potassium phosphate; 4 A molecular sieve; sulfur trioxide; tetrabutyl ammonium fluoride; sodium acetate; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; toluene; pyridinium chlorochromate; lithium chloride; lithium iodide; lithium diisopropyl amide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; mercury(II) diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 5.1: Parikh-Doering oxidation / 7.1: Suzuki coupling reaction / 10.1: Wittig reaction;
DOI:10.1016/j.tetlet.2004.09.160