Technology Process of Benzoic acid,4-[(E)-(2,3,5,6,7,8-hexahydro-5,5,8,8-tetramethyl-1H-benz[f]inden-1-ylidene)methyl]-
There total 10 articles about Benzoic acid,4-[(E)-(2,3,5,6,7,8-hexahydro-5,5,8,8-tetramethyl-1H-benz[f]inden-1-ylidene)methyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1) n-BuLi / 1) ether, hexane, r.t., 30 min, 2) ether, r.t., 5 h
2: 90.9 percent / H2 / 10percent Pd/C / 0.5 h
3: 88.6 percent / aq.NaOH / ethanol
4: 1) SOCl2, DMF, 2) AlCl3 / 1) 0 deg C, 1 h, 2) CH2Cl2, 2 h
5: 59.5 percent / NaBH4 / methanol / 0.5 h / 0 °C
6: PBr3 / diethyl ether; hexane / 1 h / 0 °C
7: 38.9 percent / benzene / Ambient temperature
8: various solvent(s) / 5 h / Heating
9: aq.KOH / methanol / 60 °C
With
potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; thionyl chloride; hydrogen; phosphorus tribromide; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; hexane; benzene;
DOI:10.1021/jm00125a027
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1) t-BuLi / 1) ether, pentane, a) r.t., 30 min, b) reflux, 30 min, 2) r.t., 30 min
2: 1) n-BuLi / 1) ether, hexane, r.t., 30 min, 2) ether, r.t., 5 h
3: 90.9 percent / H2 / 10percent Pd/C / 0.5 h
4: 88.6 percent / aq.NaOH / ethanol
5: 1) SOCl2, DMF, 2) AlCl3 / 1) 0 deg C, 1 h, 2) CH2Cl2, 2 h
6: 59.5 percent / NaBH4 / methanol / 0.5 h / 0 °C
7: PBr3 / diethyl ether; hexane / 1 h / 0 °C
8: 38.9 percent / benzene / Ambient temperature
9: various solvent(s) / 5 h / Heating
10: aq.KOH / methanol / 60 °C
With
potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; thionyl chloride; hydrogen; tert.-butyl lithium; phosphorus tribromide; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; hexane; benzene;
DOI:10.1021/jm00125a027
