N-Benzyl-N-ethyl-4-piperidinecarboxamidehydrochloride

Base Information

• Chemical Name: N-Benzyl-N-ethyl-4-piperidinecarboxamidehydrochloride
• CAS No.: 6308-67-4
• Molecular Formula: C15H22N2O
• Molecular Weight: 246.348
• Mol file: 6308-67-4.mol

Synonyms:N-benzyl-N-ethylpiperidine-4-carboxamide hydrochloride;N-Benzyl-N-ethyl-4-piperidinecarboxamide hydrochloride;

Chemical Property of N-Benzyl-N-ethyl-4-piperidinecarboxamidehydrochloride

Chemical Property:

• Vapor Pressure: 7.17E-07mmHg at 25°C
• Boiling Point: 408.1°Cat760mmHg
• Flash Point: 200.6°C
• PSA: 32.34000
• Density: 1.049g/cm³
• LogP: 3.16550

Purity/Quality:

99.5% ^*data from raw suppliers

N-Benzyl-N-ethyl-4-piperidinecarboxamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Benzyl-N-ethyl-4-piperidinecarboxamidehydrochloride

There total 4 articles about N-Benzyl-N-ethyl-4-piperidinecarboxamidehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(benzyl(ethyl)carbamoyl)piperidine-1-carboxylate (896085-01-1) → N-benzyl-N-ethylpiperidine-4-carboxamide hydrochloride (6308-67-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 1h;

DOI:10.1021/jm500995y

Reference yield:

benzylamine (100-46-9) → N-benzyl-N-ethylpiperidine-4-carboxamide hydrochloride (6308-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 4 h / 20 °C

2.1: sodium t-butanolate; 15-crown-5 / tetrahydrofuran / 0.5 h / 20 °C

2.2: 3 h / 20 °C

3.1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; 15-crown-5; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm500995y

Reference yield:

N-(tert-butoxycarbonyl)-4-(4-phenylmethyl-amidoacetyl)piperidine (188527-08-4) → N-benzyl-N-ethylpiperidine-4-carboxamide hydrochloride (6308-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium t-butanolate; 15-crown-5 / tetrahydrofuran / 0.5 h / 20 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; 15-crown-5; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/jm500995y

upstream raw materials:

N-(tert-butoxycarbonyl)-4-(4-phenylmethyl-amidoacetyl)piperidine

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

benzylamine

tert-butyl 4-(benzyl(ethyl)carbamoyl)piperidine-1-carboxylate

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