Glyfoline

Base Information

Chemical Name:Glyfoline
CAS No.:82354-35-6
Molecular Formula:C18H19NO7
Molecular Weight:361.346
Hs Code.:
DSSTox Substance ID:DTXSID50231706
Nikkaji Number:J500.317B
Wikidata:Q83112634
ChEMBL ID:CHEMBL88259
Mol file:82354-35-6.mol

Synonyms:1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one;glyfoline

Suppliers and Price of Glyfoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Glyfoline

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:618.7°Cat760mmHg
Flash Point:328°C
PSA：99.38000
Density:1.355g/cm³
LogP:2.13730
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:361.11615195
Heavy Atom Count:26
Complexity:518

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(C=CC(=C2OC)O)C(=O)C3=C1C(=C(C(=C3O)OC)OC)OC

Technology Process of Glyfoline

There total 8 articles about Glyfoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 135082-47-2
6-(benzyloxy)-1-hydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one

: 82354-35-6
des-N-methylnoracronycine

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; for 2h; under 2327.2 Torr;
DOI:10.1021/jm00092a022

Reference yield: 54.0%

: 135082-46-1
6-(benzyloxy)-10-methyl-1,2,3,4,5-pentamethoxyacridin-9-one

: 82354-35-6
des-N-methylnoracronycine

Guidance literature:: With boron tribromide; In dichloromethane; a) -78 deg C, 0.5 h, b) -78 to -20 deg C, 10 min;
DOI:10.1021/jm00092a022

Reference yield:

: 3584-32-5
4-(benzyloxy)-3-methoxy-2-nitrobenzoic acid

: 82354-35-6
des-N-methylnoracronycine

Guidance literature:: Multi-step reaction with 6 steps

1: 68.3 percent / NaOAc*3H₂O, Na₂S₂O₄ / H₂O / 4 h / 70 °C

2: 60 percent / Cu, Cu₂O, K₂CO₃ / bis-(2-methoxy-ethyl) ether / 5 h / Heating

3: SOCl₂, pyridine / benzene / 0.17 h / 0 °C

4: 1.) piperidine, Et₃N, 2.) POCl₃ / 1.) CHCl₃, RT, 20 min, 2.) 100 deg C, 30 min

5: 96 percent / K₂CO₃ / acetone / 16 h / Heating

6: 54 percent / BBr₃ / CH₂Cl₂ / a) -78 deg C, 0.5 h, b) -78 to -20 deg C, 10 min

With piperidine; pyridine; copper(I) oxide; thionyl chloride; sodium dithionite; sodium acetate; boron tribromide; copper; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; diethylene glycol dimethyl ether; water; acetone; benzene;
DOI:10.1021/jm00092a022