3584-32-5 Usage
Uses
Used in Organic Synthesis:
4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID is used as a reagent in organic synthesis for creating new molecules. Its unique functional groups allow for versatile chemical reactions, making it a valuable building block for the synthesis of complex organic compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID is used as a key intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can impart specific biological activities, contributing to the development of novel therapeutic agents.
Used in Agrochemicals:
4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID also finds applications in the agrochemical sector, where it serves as a precursor for the synthesis of various agrochemical compounds. Its incorporation into these molecules can enhance their effectiveness in pest control and crop protection.
Used in Material Science:
In the field of material science, 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID is used as a building block for the development of new materials with specific properties. Its unique chemical structure allows for the creation of materials with tailored characteristics, such as improved stability, reactivity, or selectivity, for various industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 3584-32-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,8 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3584-32:
(6*3)+(5*5)+(4*8)+(3*4)+(2*3)+(1*2)=95
95 % 10 = 5
So 3584-32-5 is a valid CAS Registry Number.
3584-32-5Relevant academic research and scientific papers
Synthesis and biological evaluation of novel analogues of the pan class i phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)
Rewcastle, Gordon W.,Gamage, Swarna A.,Flanagan, Jack U.,Frederick, Raphael,Denny, William A.,Baguley, Bruce C.,Kestell, Philip,Singh, Ripudaman,Kendall, Jackie D.,Marshall, Elaine S.,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Buchanan, Christina M.,Jamieson, Stephen M. F.,Shepherd, Peter R.
experimental part, p. 7105 - 7126 (2011/12/04)
A structure-activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2- yl]-1H-benzimidazole (ZSTK474) identified substitution at the 4 and 6 positions of the benzimidazole ring as having significant effects on the potency of substituted derivatives. The 6-amino-4-methoxy analogue displayed a greater than 1000-fold potency enhancement over the corresponding 6-aza-4-methoxy analogue against all three class Ia PI 3-kinase enzymes (p110α, p110β, and p110δ) and also displayed significant potency against two mutant forms of the p110α isoform (H1047R and E545K). This compound was also evaluated in vivo against a U87MG human glioblastoma tumor xenograft model in Rag1 -/- mice, and at a dose of 50 mg/kg given by ip injection at a qd ?- 10 dosing schedule it dramatically reduced cancer growth by 81% compared to untreated controls.
