Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-

Base Information

Chemical Name:Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-
CAS No.:61001-30-7
Molecular Formula:C18H16N2O
Molecular Weight:276.3324
Hs Code.:2933990090
UNII:PS5EAF7ZE9
DSSTox Substance ID:DTXSID00209874
Nikkaji Number:J66.473A
Wikidata:Q83084334
Mol file:61001-30-7.mol

Synonyms:61001-30-7;BRN 0673747;Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-;PS5EAF7ZE9;5,6-Dihydro-2-(3-methoxyphenyl)pyrazolo(5,1-a)isoquinoline;5-23-12-00541 (Beilstein Handbook Reference);5,6-Dihydro-2-(3-methoxyphenyl)pyrazolo[5,1-a]isoquinoline;2-(m-methoxyphenyl)-5,6-dihydro-pyrazolo[5,1-a]isoquinoline;2-(M-METHOXYPHENYL)-5,6-DIHYDRO-PYRAZOLO(5,1-A)ISOQUINOLINE;UNII-PS5EAF7ZE9;DTXSID00209874;FGGIVEYWSNKLHX-UHFFFAOYSA-N;LS-128981

Suppliers and Price of Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5,6-DIHYDRO-2-(3-METHOXYPHENYL)PYRAZOLO-[5,1-A]ISOQUINOLINE 95.00%
5MG
$ 501.99

Total 3 raw suppliers

Chemical Property of Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-

Chemical Property:

Vapor Pressure:4.61E-09mmHg at 25°C
Boiling Point:484.2°Cat760mmHg
Flash Point:246.7°C
PSA：27.05000
Density:1.2g/cm³
LogP:3.78180
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:276.126263138
Heavy Atom Count:21
Complexity:361

Purity/Quality:

99% ^*data from raw suppliers

5,6-DIHYDRO-2-(3-METHOXYPHENYL)PYRAZOLO-[5,1-A]ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=NN3CCC4=CC=CC=C4C3=C2

Technology Process of Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-

There total 8 articles about Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 61001-33-0
2-(m-hydroxyphenyl)-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

: 74-88-4
methyl iodide

: 61001-30-7
2-(m-methoxyphenyl)-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

Guidance literature:: With sodium; In ethanol; 1.) 1 h, room temp.; 2.) 60 deg C, 20 h;

Reference yield: 72.0%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 896868-57-8
1-(3-methoxyphenyl)ethanone O-acetyl oxime

: 61001-30-7
2-(m-methoxyphenyl)-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

Guidance literature:: With iron(III) oxide; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 90 ℃; for 12h; regioselective reaction; Molecular sieve;
DOI:10.1021/acs.orglett.9b02978

Reference yield:

: 39113-01-4
2-amino-3,4-dihydro-1(2H)-isoquinolinone

: 61001-30-7
2-(m-methoxyphenyl)-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid / benzene / 1 h / Heating

2: potassium t-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

3: 85 percent / 98percent H₂SO₄ / ethanol / 11 h / Heating

4: 90 percent / hydrogen / 10percent palladium on carbon / methanol / 6 h / 760 Torr / Ambient temperature

5: 85 percent / sodium / ethanol / 1.) 1 h, room temp.; 2.) 60 deg C, 20 h

With sulfuric acid; potassium tert-butylate; hydrogen; sodium; palladium on activated charcoal; toluene-4-sulfonic acid; In methanol; ethanol; tert-butyl alcohol; benzene;